Workshop cluster 1+γδ T‐cell receptor+ T cells from calves express high levels of interferon‐γ in response to stimulation with interleukin‐12 and ‐18
Summary γδ T‐cell receptor+ T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)‐γ by γδ T cells may have a role in linking innate and adaptive immune responses and contribute to T helper‐1 bias. We investigated the role of cytokines in the activat...
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| Vydané v: | Immunology Ročník 120; číslo 1; s. 57 - 65 |
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| Hlavní autori: | , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Oxford, UK
Blackwell Publishing Ltd
01.01.2007
Blackwell Publishing Inc |
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| ISSN: | 0019-2805, 1365-2567 |
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| Abstract | Summary
γδ T‐cell receptor+ T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)‐γ by γδ T cells may have a role in linking innate and adaptive immune responses and contribute to T helper‐1 bias. We investigated the role of cytokines in the activation and induction of IFN‐γ secretion by bovine workshop cluster 1+ (WC1+) γδ T cells. The effects of culture with interleukin (IL)‐12, IL‐18, IL‐15 and IL‐2 were investigated; these cytokines are known to influence murine and human γδ T cells. We report that bovine WC1+γδ T cells are synergistically stimulated by IL‐12 and IL‐18 to secrete large quantities of IFN‐γ. Neonatal calves were shown to have significantly higher numbers of circulating WC1+γδ T cells than adult animals. In addition, the response of peripheral blood WC1+γδ T cells was significantly higher in neonatal calves compared with adult animals. However, in adult animals the response of lymph node WC1+γδ T cells to IL‐12/IL‐18 was more pronounced than that of peripheral blood WC1+γδ T cells. We hypothesize that the induction of IFN‐γ secretion from WC1+γδ T cells by IL‐12 and IL‐18 is likely to be an important element of the innate response to pathogens such as Mycobacterium bovis. The high numbers of WC1+γδ T cells in neonatal calves, and their inherent ability to respond to inflammatory cytokines, could be a key factor in the enhanced responses seen in calves to BCG vaccination. |
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| AbstractList | γδ T-cell receptor+ T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)-γ by γδ T cells may have a role in linking innate and adaptive immune responses and contribute to T helper-1 bias. We investigated the role of cytokines in the activation and induction of IFN-γ secretion by bovine workshop cluster 1+ (WC1+) γδ T cells. The effects of culture with interleukin (IL)-12, IL-18, IL-15 and IL-2 were investigated; these cytokines are known to influence murine and human γδ T cells. We report that bovine WC1+γδ T cells are synergistically stimulated by IL-12 and IL-18 to secrete large quantities of IFN-γ. Neonatal calves were shown to have significantly higher numbers of circulating WC1+γδ T cells than adult animals. In addition, the response of peripheral blood WC1+γδ T cells was significantly higher in neonatal calves compared with adult animals. However, in adult animals the response of lymph node WC1+γδ T cells to IL-12/IL-18 was more pronounced than that of peripheral blood WC1+γδ T cells. We hypothesize that the induction of IFN-γ secretion from WC1+γδ T cells by IL-12 and IL-18 is likely to be an important element of the innate response to pathogens such as Mycobacterium bovis. The high numbers of WC1+γδ T cells in neonatal calves, and their inherent ability to respond to inflammatory cytokines, could be a key factor in the enhanced responses seen in calves to BCG vaccination. Summary γδ T‐cell receptor+ T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)‐γ by γδ T cells may have a role in linking innate and adaptive immune responses and contribute to T helper‐1 bias. We investigated the role of cytokines in the activation and induction of IFN‐γ secretion by bovine workshop cluster 1+ (WC1+) γδ T cells. The effects of culture with interleukin (IL)‐12, IL‐18, IL‐15 and IL‐2 were investigated; these cytokines are known to influence murine and human γδ T cells. We report that bovine WC1+γδ T cells are synergistically stimulated by IL‐12 and IL‐18 to secrete large quantities of IFN‐γ. Neonatal calves were shown to have significantly higher numbers of circulating WC1+γδ T cells than adult animals. In addition, the response of peripheral blood WC1+γδ T cells was significantly higher in neonatal calves compared with adult animals. However, in adult animals the response of lymph node WC1+γδ T cells to IL‐12/IL‐18 was more pronounced than that of peripheral blood WC1+γδ T cells. We hypothesize that the induction of IFN‐γ secretion from WC1+γδ T cells by IL‐12 and IL‐18 is likely to be an important element of the innate response to pathogens such as Mycobacterium bovis. The high numbers of WC1+γδ T cells in neonatal calves, and their inherent ability to respond to inflammatory cytokines, could be a key factor in the enhanced responses seen in calves to BCG vaccination. γδ T‐cell receptor + T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)‐γ by γδ T cells may have a role in linking innate and adaptive immune responses and contribute to T helper‐1 bias. We investigated the role of cytokines in the activation and induction of IFN‐γ secretion by bovine workshop cluster 1 + (WC1 + ) γδ T cells. The effects of culture with interleukin (IL)‐12, IL‐18, IL‐15 and IL‐2 were investigated; these cytokines are known to influence murine and human γδ T cells. We report that bovine WC1 + γδ T cells are synergistically stimulated by IL‐12 and IL‐18 to secrete large quantities of IFN‐γ. Neonatal calves were shown to have significantly higher numbers of circulating WC1 + γδ T cells than adult animals. In addition, the response of peripheral blood WC1 + γδ T cells was significantly higher in neonatal calves compared with adult animals. However, in adult animals the response of lymph node WC1 + γδ T cells to IL‐12/IL‐18 was more pronounced than that of peripheral blood WC1 + γδ T cells. We hypothesize that the induction of IFN‐γ secretion from WC1 + γδ T cells by IL‐12 and IL‐18 is likely to be an important element of the innate response to pathogens such as Mycobacterium bovis. The high numbers of WC1 + γδ T cells in neonatal calves, and their inherent ability to respond to inflammatory cytokines, could be a key factor in the enhanced responses seen in calves to BCG vaccination. |
| Author | Hope, Jayne C. Howard, Christopher J. Price, Sally J. Sopp, Paul |
| Author_xml | – sequence: 1 givenname: Sally J. surname: Price fullname: Price, Sally J. – sequence: 2 givenname: Paul surname: Sopp fullname: Sopp, Paul – sequence: 3 givenname: Christopher J. surname: Howard fullname: Howard, Christopher J. – sequence: 4 givenname: Jayne C. surname: Hope fullname: Hope, Jayne C. |
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γδ T‐cell receptor+ T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)‐γ by γδ T cells may have a... γδ T‐cell receptor + T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)‐γ by γδ T cells may have a role... γδ T-cell receptor+ T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)-γ by γδ T cells may have a role in... |
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| SubjectTerms | bovine interferon‐γ interleukin‐12 neonatal Original workshop cluster 1+γδ T cells |
| Title | Workshop cluster 1+γδ T‐cell receptor+ T cells from calves express high levels of interferon‐γ in response to stimulation with interleukin‐12 and ‐18 |
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