Factor v Leiden mutation in severe infection and sepsis

In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with an increased tendency to develop thrombosis....

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Bibliographic Details
Published in:Seminars in thrombosis and hemostasis Vol. 37; no. 8; p. 955
Main Authors: Levi, Marcel, Schouten, Marcel, van't Veer, Cees, van der Poll, Tom
Format: Journal Article
Language:English
Published: United States 01.11.2011
Subjects:
Animals
Factor V - genetics
Humans
Infection - blood
Infection - genetics
Mice
Mutation
Sepsis - blood
Sepsis - genetics
Thrombophilia - blood
Thrombophilia - genetics
Thrombophilia - microbiology
ISSN:1098-9064, 1098-9064
Online Access:Get more information
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Summary:In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with an increased tendency to develop thrombosis. Hypothetically, patients with factor V Leiden may suffer from more severe coagulopathy in cases of severe infection or sepsis. Aggravation of the procoagulant state in sepsis may subsequently result in more severe organ dysfunction and an increased risk of death. In this article we review the experimental and clinical evidence regarding the relationship between the presence of a factor V Leiden mutation and the incidence and outcome of sepsis.
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ISSN:1098-9064
1098-9064
DOI:10.1055/s-0031-1297374