Factor v Leiden mutation in severe infection and sepsis

In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with an increased tendency to develop thrombosis....

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Seminars in thrombosis and hemostasis Jg. 37; H. 8; S. 955
Hauptverfasser: Levi, Marcel, Schouten, Marcel, van't Veer, Cees, van der Poll, Tom
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.11.2011
Schlagworte:
Animals
Factor V - genetics
Humans
Infection - blood
Infection - genetics
Mice
Mutation
Sepsis - blood
Sepsis - genetics
Thrombophilia - blood
Thrombophilia - genetics
Thrombophilia - microbiology
ISSN:1098-9064, 1098-9064
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In severe infection and sepsis, activation of coagulation frequently occurs, which contributes to the development of multiple organ dysfunction. Factor V Leiden is a relatively common mutation resulting in a mild prohemostatic state and consequently with an increased tendency to develop thrombosis. Hypothetically, patients with factor V Leiden may suffer from more severe coagulopathy in cases of severe infection or sepsis. Aggravation of the procoagulant state in sepsis may subsequently result in more severe organ dysfunction and an increased risk of death. In this article we review the experimental and clinical evidence regarding the relationship between the presence of a factor V Leiden mutation and the incidence and outcome of sepsis.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1098-9064
1098-9064
DOI:10.1055/s-0031-1297374