Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to systemic sclerosis: a meta-analysis

The purpose of this study was to examine whether the insertion (I) or deletion (D) polymorphism of the angiotensin-converting enzyme gene (ACE) is associated with susceptibility to systemic sclerosis (SSc). A meta-analysis examining the associations between the ACE I/D polymorphism and SSc was condu...

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Vydané v:Genetics and molecular research Ročník 13; číslo 4; s. 8174 - 8183
Hlavní autori: Song, G.G., Lee, Y.H.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Brazil 07.10.2014
Predmet:
Alleles
Continental Population Groups - genetics
Gene Frequency
Genetic Predisposition to Disease
Humans
INDEL Mutation
Odds Ratio
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic
Scleroderma, Systemic - genetics
ISSN:1676-5680, 1676-5680
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Shrnutí:The purpose of this study was to examine whether the insertion (I) or deletion (D) polymorphism of the angiotensin-converting enzyme gene (ACE) is associated with susceptibility to systemic sclerosis (SSc). A meta-analysis examining the associations between the ACE I/D polymorphism and SSc was conducted in overall and European populations using 1) allelic contrast (D vs I); 2) recessive (DD vs ID + II); 3) dominant (DD + ID vs II); and 4) additive (DD vs ID vs II) models. A total of 7 studies consisting of 837 cases and 754 controls were available for meta-analysis. The meta-analysis revealed no association between the D allele and SSc in any study subjects [odds ratio (OR) = 0.956, 95% confidence interval (CI) = 0.733-1.246, P = 0.737]. Stratification by ethnicity indicated no association between the D allele of the ACE I/D polymorphism and SSc in Europeans (OR = 1.117, 95%CI = 0.776-1.607, P = 0.551). Meta-analysis using all other genetic models showed the same D allele pattern in the overall and European groups. This meta-analysis showed that the ACE I/D polymorphism was not associated with susceptibility to SSc in the study subjects and in Europeans.
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content type line 23
ISSN:1676-5680
1676-5680
DOI:10.4238/2014.October.7.12