A simple and robust algorithm for microarray data clustering based on gene population-variance ratio metric

With the advent of the microarray technology, the field of life science has been greatly revolutionized, since this technique allows the simultaneous monitoring of the expression levels of thousands of genes in a particular organism. However, the statistical analysis of expression data has its own c...

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Veröffentlicht in:Biotechnology journal Jg. 4; H. 9; S. 1357 - 1361
Hauptverfasser: Chatterjee, Soumyadeep, Bhattacharjee, Kasturi, Konar, Amit
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Weinheim WILEY-VCH Verlag 01.09.2009
WILEY‐VCH Verlag
Schlagworte:
Algorithms
Cluster Analysis
Computer Simulation
Gene clustering
Gene expression
Gene Expression Profiling - methods
Microarray data
Models, Genetic
Oligonucleotide Array Sequence Analysis - methods
Variance
ISSN:1860-6768, 1860-7314, 1860-7314
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Zusammenfassung:With the advent of the microarray technology, the field of life science has been greatly revolutionized, since this technique allows the simultaneous monitoring of the expression levels of thousands of genes in a particular organism. However, the statistical analysis of expression data has its own challenges, primarily because of the huge amount of data that is to be dealt with, and also because of the presence of noise, which is almost an inherent characteristic of microarray data. Clustering is one tool used to mine meaningful patterns from microarray data. In this paper, we present a novel method of clustering yeast microarray data, which is robust and yet simple to implement. It identifies the best clusters from a given dataset on the basis of the population of the clusters as well as the variance of the feature values of the members from the cluster‐center. It has been found to yield satisfactory results even in the presence of noisy data.
Bibliographie:ark:/67375/WNG-XSDQWBRT-B
istex:7448AA14FD2AF388BFCD920695E5690D3DDC0156
ArticleID:BIOT200800219
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1860-6768
1860-7314
1860-7314
DOI:10.1002/biot.200800219