Stromal heterogeneity in the adult lung delineated by single-cell genomics

Stromal cells in the lung provide structural support to other cells and play critical roles in inflammation, repair, and fibrosis after injury. Recent technological advancements in single-cell genomics have tremendously improved our knowledge of stromal heterogeneity in the lung. Stromal heterogenei...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology Vol. 328; no. 6; p. C1964
Main Authors: Tsukui, Tatsuya, Sheppard, Dean
Format: Journal Article
Language:English
Published: United States 01.06.2025
Subjects:
Animals
Genomics - methods
Humans
Lung - cytology
Lung - metabolism
Lung - pathology
Single-Cell Analysis - methods
Stromal Cells - metabolism
Stromal Cells - pathology
lung
stromal cell
fibrosis
fibroblast
injury
ISSN:1522-1563, 1522-1563
Online Access:Get more information
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Summary:Stromal cells in the lung provide structural support to other cells and play critical roles in inflammation, repair, and fibrosis after injury. Recent technological advancements in single-cell genomics have tremendously improved our knowledge of stromal heterogeneity in the lung. Stromal heterogeneity in single-cell RNA sequencing data is often conserved across different studies despite the different annotation strategies. Spatial analyses suggest that each stromal subset is characterized by unique anatomic locations in the adult lung. This review overviews the stromal heterogeneity delineated by single-cell RNA sequencing studies and highlights the functional characteristics and locations of each population.
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ISSN:1522-1563
1522-1563
DOI:10.1152/ajpcell.00285.2025