Release and Activity of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 by Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease

Destruction of lung elastin is critical for development of emphysema associated with chronic obstructive pulmonary disease (COPD). Lung macrophages release elastolytic enzymes, including matrix metalloproteinase (MMP)-9, along with tissue inhibitors of MMP (TIMP). We examined the production and acti...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology Jg. 26; H. 5; S. 602 - 609
Hauptverfasser:	Russell, Richard E. K, Culpitt, Sarah V, DeMatos, Carmen, Donnelly, Louise, Smith, Michael, Wiggins, John, Barnes, Peter J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Am Thoracic Soc 01.05.2002
Schlagworte:	Aged Bronchoalveolar Lavage Fluid - cytology Cell Count Cells, Cultured Culture Media, Conditioned - pharmacology Dexamethasone - pharmacology Dose-Response Relationship, Drug Enzyme Activation - drug effects Female Glucocorticoids - pharmacology Humans Interleukin-1 - pharmacology Lipopolysaccharides - pharmacology Macrophages, Alveolar - cytology Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Male Matrix Metalloproteinase 9 - biosynthesis Middle Aged Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - pathology Smoking - metabolism Smoking - pathology Tissue Inhibitor of Metalloproteinase-1 - biosynthesis Tobacco Smoke Pollution
ISSN:	1044-1549, 1535-4989
Online-Zugang:	Volltext
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