Statistical models for recurrent events and death: Application to cancer events

In many biomedical studies, subjects may experience the outcome of interest more than once over a period of observation; outcomes of this sort have been termed recurrent events. A model that is becoming increasingly popular for modeling association between recurrent survival times is the use of a fr...

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Bibliographic Details
Published in:Mathematical and computer modelling Vol. 52; no. 7; pp. 949 - 955
Main Author: Rondeau, V.
Format: Journal Article Conference Proceeding
Language:English
Published: Kidlington Elsevier Ltd 01.10.2010
Elsevier
Subjects:
Correlated survival times
Cure frailty model
Exact sciences and technology
Frailty models
Joint frailty model
Mathematical analysis
Mathematics
Methods of scientific computing (including symbolic computation, algebraic computation)
Nested frailty model
Numerical analysis. Scientific computation
Penalized likelihood
Sciences and techniques of general use
Cure frailty model
Nested frailty model
Penalized likelihood
Frailty models
Correlated survival times
Joint frailty model
Parameter estimation
Applied mathematics
Mathematical model
Penalty method
Computer aided analysis
ISSN:0895-7177, 1872-9479
Online Access:Get full text
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Summary:In many biomedical studies, subjects may experience the outcome of interest more than once over a period of observation; outcomes of this sort have been termed recurrent events. A model that is becoming increasingly popular for modeling association between recurrent survival times is the use of a frailty model. In recent years a number of papers appeared, extending the survival models to models that are suitable to handle more complex survival data as recurrent events. We present here frailty model extensions to analyze recurrent events data: cure frailty models for a mixture of susceptible and insusceptible subjects for the event of interest; nested frailty models when data are clustered at several hierarchical levels and joint frailty models for the joint analysis of recurrent events and death. We performed a semi-parametric penalized likelihood approach to estimate the different parameters. Those different models can be fitted using the R package “frailtypack”.
ISSN:0895-7177
1872-9479
DOI:10.1016/j.mcm.2010.02.002