Properties governing small-molecule partitioning into biomolecular condensates

Membraneless cellular assemblies termed biomolecular condensates — into which diverse biopolymers partition — mediate myriad biological processes. A study now reveals that physicochemical features, not specific stereochemistry, influence whether small molecules are enriched within or excluded from a...

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Vydané v:Nature chemistry Ročník 16; číslo 11; s. 1743 - 1745
Hlavní autori: Chandra, Bappaditya, Tripathi, Swarnendu, Kriwacki, Richard
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 01.11.2024
Nature Publishing Group
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631/92/613
639/638/92/507
Analytical Chemistry
Biochemistry
Biological activity
Biological properties
Biopolymers
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Condensates
Drug development
Inorganic Chemistry
Machine learning
Mass spectrometry
Metabolites
News & Views
news-and-views
Organic Chemistry
Physical Chemistry
R&D
Research & development
Scientific imaging
Stereochemistry
ISSN:1755-4330, 1755-4349, 1755-4349
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Shrnutí:Membraneless cellular assemblies termed biomolecular condensates — into which diverse biopolymers partition — mediate myriad biological processes. A study now reveals that physicochemical features, not specific stereochemistry, influence whether small molecules are enriched within or excluded from a diverse panel of condensates.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1755-4330
1755-4349
1755-4349
DOI:10.1038/s41557-024-01655-1