Poor kidney graft survival in anorexia nervosa patients

Background Anorexia nervosa is a condition associated with poor outcomes in a variety of circumstances such as recurrence of eating disorders, psychiatric disorders, and organ damage. Objective In the present study, we first sought to determine the 5-year kidney graft survival in patients with anore...

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Bibliographic Details
Published in:Eating and weight disorders Vol. 26; no. 5; pp. 1447 - 1455
Main Authors: Geneviève, Magalie, Sartorius, Albane, Giral, Magali, Janbon, Bénédicte, Merville, Pierre, Legendre, Christophe, Combe, Christian, Moreau, Karine
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01.06.2021
Springer Nature B.V
Subjects:
Anorexia
Body mass index
Bulimia
Cytomegalovirus
Kidney diseases
Kidney transplants
Medical records
Medicine
Medicine & Public Health
Mental disorders
Mortality
Obesity
Original Article
Peritoneal dialysis
Psychiatry
Weight control
Body mass index
Graft survival
Anorexia nervosa
Kidney transplantation
ISSN:1590-1262, 1124-4909, 1590-1262
Online Access:Get full text
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Summary:Background Anorexia nervosa is a condition associated with poor outcomes in a variety of circumstances such as recurrence of eating disorders, psychiatric disorders, and organ damage. Objective In the present study, we first sought to determine the 5-year kidney graft survival in patients with anorexia nervosa and then to evaluate the BMI course and medical complications. Methods In this multicenter, retrospective, case–control study, we analyzed the impact of anorexia nervosa on graft outcomes compared to transplant recipients with low or normal BMI. Results We enrolled 137 women in this study: 19 with anorexia nervosa, 59 with low BMI (BMI < 18.5 kg/m 2 ), and 59 with normal BMI (18.5–24.9 kg/m 2 ). Anorexia nervosa was significantly associated with lower graft survival compared to either of the other groups (hazard ratio 5.5 [95% CI 3.4–8.9], p  = 0.005); there was no difference in graft survival between patients with low or normal BMI. Cardiovascular complications were more frequent in the anorexia nervosa group (37%) than in patients with low (6%) or normal BMI (7%) ( p  = 0.001). Conclusion We conclude that patients with anorexia nervosa should be considered a high-risk group. Level of evidence Level III, evidence obtained from well-designed cohort or case–control analytic studies.
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ISSN:1590-1262
1124-4909
1590-1262
DOI:10.1007/s40519-020-00959-8