Chloroquine sensitises hypoxic colorectal cancer cells to ROS-mediated cell death via structural disruption of pyruvate dehydrogenase kinase 1

Chloroquine (CQ), an autophagy antagonist, has been recently explored as a repurposable medicine for cancer; however the exact mechanism of its action is still not known. The present study investigated the effect of CQ on colorectal cancer cells to elucidate the underlying molecular mechanisms. We r...

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Veröffentlicht in:	Free radical biology & medicine Jg. 227; S. 656 - 666
Hauptverfasser:	Mir, Irfan Ahmad, Mir, Hilal Ahmad, Mehraj, Umar, Bhat, Mohd Younus, Mir, Manzoor Ahmad, Dar, Tanveer Ali, Hussain, Mahboob-Ul
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.02.2025
Schlagworte:	And apoptosis Apoptosis - drug effects Autophagy - drug effects Cell Hypoxia Cell Proliferation - drug effects Cell Survival - drug effects Chloroquine - pharmacology Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology CQ-Binding CQ-Repositioning Glycolysis Glycolysis - drug effects HCT116 Cells Humans Hypoxia Membrane Potential, Mitochondrial - drug effects Mitochondria - drug effects Mitochondria - metabolism MMP PDK1 Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - chemistry Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Pyruvate Dehydrogenase Acetyl-Transferring Kinase Reactive Oxygen Species - metabolism ROS MMP And apoptosis CQ-Repositioning Colorectal cancer ROS Glycolysis Hypoxia PDK1 CQ-Binding
ISSN:	0891-5849, 1873-4596, 1873-4596
Online-Zugang:	Volltext
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