A widespread plant defense compound disarms bacterial type III injectisome assembly

Numerous gram-negative bacterial pathogens employ the type III secretion system (T3SS), a multiprotein injectisome, to deliver virulence proteins into host cells and cause diseases. We uncover erucamide as a previously unknown phytoalexin of both dicots and monocots that blocks the T3SS function of...

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Vydáno v:	Science (American Association for the Advancement of Science) Ročník 387; číslo 6737; s. eads0377
Hlavní autoři:	Miao, Pei, Wang, Haijun, Wang, Wei, Wang, Zhengdong, Ke, Han, Cheng, Hangyuan, Ni, Jinjing, Liang, Jingnan, Yao, Yu-Feng, Wang, Jizong, Zhou, Jian-Min, Lei, Xiaoguang
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 28.02.2025
Témata:	Arabidopsis - genetics Arabidopsis - immunology Arabidopsis - metabolism Arabidopsis - microbiology Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Bacterial Outer Membrane Proteins - antagonists & inhibitors Bacterial Outer Membrane Proteins - metabolism Bacterial Proteins - metabolism Disease Resistance Erucic Acids - metabolism Erucic Acids - pharmacology Phytoalexins - metabolism Phytoalexins - pharmacology Plant Diseases - immunology Plant Diseases - microbiology Pseudomonas syringae - drug effects Pseudomonas syringae - pathogenicity Sesquiterpenes - chemistry Sesquiterpenes - metabolism Sesquiterpenes - pharmacology Type III Secretion Systems - antagonists & inhibitors Type III Secretion Systems - genetics Type III Secretion Systems - metabolism Virulence
ISSN:	1095-9203, 1095-9203
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