Type-IIA secreted phospholipase A2 is an endogenous antibiotic-like protein of the host

Type-IIA secreted phospholipase A(2) (sPLA(2)-IIA) has been proposed to play a role in the development of inflammatory diseases. It has been shown to release arachidonic acid, the precursor of proinflammatory eicosanoids, to hydrolyze phospholipids of pulmonary surfactant, and to bind to specific re...

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Bibliographic Details
Published in:	Biochimie Vol. 92; no. 6; pp. 583 - 587
Main Authors:	Wu, Yongzheng, Raymond, Benoît, Goossens, Pierre L., Njamkepo, Elisabeth, Guiso, Nicole, Paya, Miguel, Touqui, Lhousseine
Format:	Journal Article
Language:	English
Published:	France Elsevier 01.06.2010
Subjects:	Animals Anthrax - immunology Anti-Bacterial Agents - pharmacology Antigens, Bacterial - immunology Arachidonic Acid - metabolism Bacillus anthracis - immunology Bacillus anthracis - pathogenicity Bacterial Toxins - antagonists & inhibitors Drug Resistance, Microbial - immunology Group II Phospholipases A2 - metabolism Group II Phospholipases A2 - pharmacology Host-Pathogen Interactions Humans Immunology Life Sciences Mice Vaccinology
ISSN:	0300-9084, 1638-6183, 1638-6183
Online Access:	Get full text
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