Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein-Barr virus (EBV) in a cohort comprising more than 10 million young adults on active duty in the US military, 955 of whom we...

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Vydáno v:Science (American Association for the Advancement of Science) Ročník 375; číslo 6578; s. 296
Hlavní autoři: Bjornevik, Kjetil, Cortese, Marianna, Healy, Brian C, Kuhle, Jens, Mina, Michael J, Leng, Yumei, Elledge, Stephen J, Niebuhr, David W, Scher, Ann I, Munger, Kassandra L, Ascherio, Alberto
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 21.01.2022
Témata:
Age of Onset
Antibodies, Viral - blood
Biomarkers - blood
Cohort Studies
Cytomegalovirus - immunology
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - epidemiology
Female
Herpesvirus 4, Human - immunology
Humans
Longitudinal Studies
Male
Military Personnel
Multiple Sclerosis - epidemiology
Multiple Sclerosis - etiology
Multiple Sclerosis - virology
Neurofilament Proteins - blood
Prevalence
Risk Factors
Young Adult
ISSN:1095-9203, 1095-9203
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Popis
Shrnutí:Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein-Barr virus (EBV) in a cohort comprising more than 10 million young adults on active duty in the US military, 955 of whom were diagnosed with MS during their period of service. Risk of MS increased 32-fold after infection with EBV but was not increased after infection with other viruses, including the similarly transmitted cytomegalovirus. Serum levels of neurofilament light chain, a biomarker of neuroaxonal degeneration, increased only after EBV seroconversion. These findings cannot be explained by any known risk factor for MS and suggest EBV as the leading cause of MS.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1095-9203
1095-9203
DOI:10.1126/science.abj8222