miR-731 modulates the zebrafish heart morphogenesis via targeting Calcineurin/Nfatc3a pathway

Zebrafish miR-731 is orthologous of human miR-425, which has been demonstrated to have cardio-protective roles by a variety of mechanisms. The miR-731 morphants show pericardium enlargement, and many DEGs (differentially expressed genes) are enriched in ‘Cardiac muscle contraction’ and ‘Calcium sign...

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Vydáno v:	Biochimica et biophysica acta. General subjects Ročník 1866; číslo 6; s. 130133
Hlavní autoři:	Huang, Yan, Wang, Wei-Feng, Huang, Chun-Xiao, Li, Xuan-Hui, Liu, Hong, Wang, Huan-Ling
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 01.06.2022
Témata:	Animals Calcineurin - genetics Calcineurin - metabolism Calcineurin/Nfatc3a calcium cardiac output Danio rerio Development gene expression gene expression regulation genes Heart heart rate humans hybridization luciferase MicroRNAs - genetics MicroRNAs - metabolism miR-731 morphogenesis Morphogenesis - genetics muscle contraction myocardium pericardium sequence analysis Western blotting Zebrafish Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Heart Development Calcineurin/Nfatc3a Zebrafish miR-731
ISSN:	0304-4165, 1872-8006, 1872-8006
On-line přístup:	Získat plný text
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