Systems biology characterization of engineered tissues

Tissue engineering and molecular systems biology are inherently interdisciplinary fields that have been developed independently so far. In this review, we first provide a brief introduction to tissue engineering and to molecular systems biology. Next, we highlight some prominent applications of syst...

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Bibliographic Details
Published in:Annual review of biomedical engineering Vol. 15; p. 55
Main Authors: Rajagopalan, Padmavathy, Kasif, Simon, Murali, T M
Format: Journal Article
Language:English
Published: United States 01.01.2013
Subjects:
Algorithms
Animals
Bioengineering - methods
Computational Biology - methods
Humans
Microfluidics - methods
Protein Interaction Mapping - methods
Systems Biology - methods
Tissue Engineering - methods
ISSN:1545-4274, 1545-4274
Online Access:Get more information
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Summary:Tissue engineering and molecular systems biology are inherently interdisciplinary fields that have been developed independently so far. In this review, we first provide a brief introduction to tissue engineering and to molecular systems biology. Next, we highlight some prominent applications of systems biology techniques in tissue engineering. Finally, we outline research directions that can successfully blend these two fields. Through these examples, we propose that experimental and computational advances in molecular systems biology can lead to predictive models of bioengineered tissues that enhance our understanding of bioengineered systems. In turn, the unique challenges posed by tissue engineering will usher in new experimental techniques and computational advances in systems biology.
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ISSN:1545-4274
1545-4274
DOI:10.1146/annurev-bioeng-071811-150120