A platinum complex that binds non-covalently to DNA and induces cell death via a different mechanism than cisplatin

Cisplatin and some of its derivatives have been shown to be very successful anticancer agents. Their main mode of action has been proposed to be via covalent binding to DNA. However, one of the limitations of these drugs is their poor activity against some tumours due to intrinsic or acquired resist...

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Veröffentlicht in:Metallomics Jg. 5; H. 5; S. 514
Hauptverfasser: Suntharalingam, Kogularamanan, Mendoza, Oscar, Duarte, Alexandra A, Mann, David J, Vilar, Ramon
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 01.05.2013
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ISSN:1756-591X, 1756-591X
Online-Zugang:Weitere Angaben
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