Gene Expression Microarray Data Analysis for Toxicology Profiling

: When dealing with thousands of genes, all potentially interesting, it is desirable to rank the genes according to their degree of participation in a physiological process. Therefore, genes with the highest Shannon entropy and ERL can be selected as the best toxicity target candidates, permitting p...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences Vol. 919; no. 1; pp. 52 - 67
Main Authors: CUNNINGHAM, M. J., LIANG, S., FURMAN, S., SEILHAMER, J. J., SOMOGYI, R.
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01.09.2000
Subjects:
Acetaminophen - pharmacology
Animals
Benzo(a)pyrene - pharmacology
Clofibrate - pharmacology
Drug-Related Side Effects and Adverse Reactions - genetics
Entropy
Gene Expression - drug effects
Gene Expression Profiling
Liver - drug effects
Liver - metabolism
Liver - pathology
Male
Oligonucleotide Array Sequence Analysis
Organ Size - drug effects
Rats
Rats, Sprague-Dawley
RNA, Messenger - analysis
RNA, Messenger - genetics
Toxicity Tests - methods
ISSN:0077-8923, 1749-6632
Online Access:Get full text
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Summary:: When dealing with thousands of genes, all potentially interesting, it is desirable to rank the genes according to their degree of participation in a physiological process. Therefore, genes with the highest Shannon entropy and ERL can be selected as the best toxicity target candidates, permitting preclinical scientists to focus their research and resources on those genes.
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ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2000.tb06867.x