Sedentary behavior, brain-derived neurotrophic factor and brain structure in midlife: A longitudinal brain MRI sub-study of the coronary artery risk development in young adults study
Brain-derived neurotrophic factor levels are higher in those who are physically active and lower in people with cognitive dysfunction. This study investigated whether brain-derived neurotrophic factor mediated or modified the association of sedentary time to MRI-estimated brain volumes in midlife. B...
Saved in:
| Published in: | Frontiers in dementia Vol. 2; p. 1110553 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Switzerland
Frontiers Media S.A
13.03.2023
|
| Subjects: | |
| ISSN: | 2813-3919, 2813-3919 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Brain-derived neurotrophic factor levels are higher in those who are physically active and lower in people with cognitive dysfunction. This study investigated whether brain-derived neurotrophic factor mediated or modified the association of sedentary time to MRI-estimated brain volumes in midlife.
Baseline (
= 612) and five-year follow-up (
= 418) data were drawn from the multicenter Coronary Artery Risk Development in Young Adults Brain MRI sub-study, including Black and White participants (aged 50.3 years, 51.6% females, 38.6% Black). Sedentary time (hours per day) was categorized into quartiles with low ≤ 4.3 (reference) and high > 8.4. Outcomes of the study were total brain, white matter, gray matter, hippocampal volumes, and white matter fractional anisotropy at baseline and 5-year percent change from baseline. The study used general linear regression models to examine the mediation and moderation effects of brain-derived neurotrophic factor (natural log transformed) on the associations of sedentary time to brain outcomes. The authors adjusted the regression model for age, sex, race, intracranial volume, education, and vascular factors.
Cross-sectionally, baseline participants with the highest sedentary time had a lower total brain (-12.2 cc; 95%CI: -20.7, -3.7), gray matter (-7.8 cc; 95%CI: -14.3, -1.3), and hippocampal volume (-0.2 cc; 95%CI: -0.3, 0.0) compared with populations with the lowest sedentary time. The brain-derived neurotrophic factor levels did not mediate the associations between brain measures and sedentary time. Brain-derived neurotrophic factor was found to moderate associations of sedentary time to total brain and white matter volume such that the brain volume difference between high and low sedentary time decreased as brain-derived neurotrophic factor levels increased. Longitudinally, higher baseline brain-derived neurotrophic factor level was associated with less brain volume decline. The longitudinal associations did not differ by sedentary time, and brain-derived neurotrophic factor did not mediate or moderate the association of sedentary time to brain measure changes.
Higher brain-derived neurotrophic factor levels may buffer the negative effects of sedentary time on the brain. |
|---|---|
| AbstractList | Brain-derived neurotrophic factor levels are higher in those who are physically active and lower in people with cognitive dysfunction. This study investigated whether brain-derived neurotrophic factor mediated or modified the association of sedentary time to MRI-estimated brain volumes in midlife.
Baseline (
= 612) and five-year follow-up (
= 418) data were drawn from the multicenter Coronary Artery Risk Development in Young Adults Brain MRI sub-study, including Black and White participants (aged 50.3 years, 51.6% females, 38.6% Black). Sedentary time (hours per day) was categorized into quartiles with low ≤ 4.3 (reference) and high > 8.4. Outcomes of the study were total brain, white matter, gray matter, hippocampal volumes, and white matter fractional anisotropy at baseline and 5-year percent change from baseline. The study used general linear regression models to examine the mediation and moderation effects of brain-derived neurotrophic factor (natural log transformed) on the associations of sedentary time to brain outcomes. The authors adjusted the regression model for age, sex, race, intracranial volume, education, and vascular factors.
Cross-sectionally, baseline participants with the highest sedentary time had a lower total brain (-12.2 cc; 95%CI: -20.7, -3.7), gray matter (-7.8 cc; 95%CI: -14.3, -1.3), and hippocampal volume (-0.2 cc; 95%CI: -0.3, 0.0) compared with populations with the lowest sedentary time. The brain-derived neurotrophic factor levels did not mediate the associations between brain measures and sedentary time. Brain-derived neurotrophic factor was found to moderate associations of sedentary time to total brain and white matter volume such that the brain volume difference between high and low sedentary time decreased as brain-derived neurotrophic factor levels increased. Longitudinally, higher baseline brain-derived neurotrophic factor level was associated with less brain volume decline. The longitudinal associations did not differ by sedentary time, and brain-derived neurotrophic factor did not mediate or moderate the association of sedentary time to brain measure changes.
Higher brain-derived neurotrophic factor levels may buffer the negative effects of sedentary time on the brain. Brain-derived neurotrophic factor levels are higher in those who are physically active and lower in people with cognitive dysfunction. This study investigated whether brain-derived neurotrophic factor mediated or modified the association of sedentary time to MRI-estimated brain volumes in midlife.BackgroundBrain-derived neurotrophic factor levels are higher in those who are physically active and lower in people with cognitive dysfunction. This study investigated whether brain-derived neurotrophic factor mediated or modified the association of sedentary time to MRI-estimated brain volumes in midlife.Baseline (n = 612) and five-year follow-up (n = 418) data were drawn from the multicenter Coronary Artery Risk Development in Young Adults Brain MRI sub-study, including Black and White participants (aged 50.3 years, 51.6% females, 38.6% Black). Sedentary time (hours per day) was categorized into quartiles with low ≤ 4.3 (reference) and high > 8.4. Outcomes of the study were total brain, white matter, gray matter, hippocampal volumes, and white matter fractional anisotropy at baseline and 5-year percent change from baseline. The study used general linear regression models to examine the mediation and moderation effects of brain-derived neurotrophic factor (natural log transformed) on the associations of sedentary time to brain outcomes. The authors adjusted the regression model for age, sex, race, intracranial volume, education, and vascular factors.MethodsBaseline (n = 612) and five-year follow-up (n = 418) data were drawn from the multicenter Coronary Artery Risk Development in Young Adults Brain MRI sub-study, including Black and White participants (aged 50.3 years, 51.6% females, 38.6% Black). Sedentary time (hours per day) was categorized into quartiles with low ≤ 4.3 (reference) and high > 8.4. Outcomes of the study were total brain, white matter, gray matter, hippocampal volumes, and white matter fractional anisotropy at baseline and 5-year percent change from baseline. The study used general linear regression models to examine the mediation and moderation effects of brain-derived neurotrophic factor (natural log transformed) on the associations of sedentary time to brain outcomes. The authors adjusted the regression model for age, sex, race, intracranial volume, education, and vascular factors.Cross-sectionally, baseline participants with the highest sedentary time had a lower total brain (-12.2 cc; 95%CI: -20.7, -3.7), gray matter (-7.8 cc; 95%CI: -14.3, -1.3), and hippocampal volume (-0.2 cc; 95%CI: -0.3, 0.0) compared with populations with the lowest sedentary time. The brain-derived neurotrophic factor levels did not mediate the associations between brain measures and sedentary time. Brain-derived neurotrophic factor was found to moderate associations of sedentary time to total brain and white matter volume such that the brain volume difference between high and low sedentary time decreased as brain-derived neurotrophic factor levels increased. Longitudinally, higher baseline brain-derived neurotrophic factor level was associated with less brain volume decline. The longitudinal associations did not differ by sedentary time, and brain-derived neurotrophic factor did not mediate or moderate the association of sedentary time to brain measure changes.ResultsCross-sectionally, baseline participants with the highest sedentary time had a lower total brain (-12.2 cc; 95%CI: -20.7, -3.7), gray matter (-7.8 cc; 95%CI: -14.3, -1.3), and hippocampal volume (-0.2 cc; 95%CI: -0.3, 0.0) compared with populations with the lowest sedentary time. The brain-derived neurotrophic factor levels did not mediate the associations between brain measures and sedentary time. Brain-derived neurotrophic factor was found to moderate associations of sedentary time to total brain and white matter volume such that the brain volume difference between high and low sedentary time decreased as brain-derived neurotrophic factor levels increased. Longitudinally, higher baseline brain-derived neurotrophic factor level was associated with less brain volume decline. The longitudinal associations did not differ by sedentary time, and brain-derived neurotrophic factor did not mediate or moderate the association of sedentary time to brain measure changes.Higher brain-derived neurotrophic factor levels may buffer the negative effects of sedentary time on the brain.ConclusionsHigher brain-derived neurotrophic factor levels may buffer the negative effects of sedentary time on the brain. |
| Author | Meirelles, Osorio D. Zhang, Xuan Yaffe, Kristine Li, Zhiguang Qiu, Chengxuan Launer, Lenore J. Bryan, R. Nick |
| AuthorAffiliation | 1 Laboratory of Epidemiology and Population Sciences Intramural Research Program, National Institute on Aging , Baltimore, MD , United States 2 Departments of Psychiatry and Behavioral Sciences, Neurology, and Epidemiology, University of California, San Francisco , San Francisco, CA , United States 3 Department of Radiology, University of Pennsylvania , Philadelphia, PA , United States 4 Aging Research Center and Center for Alzheimer's Research, Karolinska Institutet , Stockholm , Sweden |
| AuthorAffiliation_xml | – name: 4 Aging Research Center and Center for Alzheimer's Research, Karolinska Institutet , Stockholm , Sweden – name: 3 Department of Radiology, University of Pennsylvania , Philadelphia, PA , United States – name: 1 Laboratory of Epidemiology and Population Sciences Intramural Research Program, National Institute on Aging , Baltimore, MD , United States – name: 2 Departments of Psychiatry and Behavioral Sciences, Neurology, and Epidemiology, University of California, San Francisco , San Francisco, CA , United States |
| Author_xml | – sequence: 1 givenname: Xuan surname: Zhang fullname: Zhang, Xuan – sequence: 2 givenname: Osorio D. surname: Meirelles fullname: Meirelles, Osorio D. – sequence: 3 givenname: Zhiguang surname: Li fullname: Li, Zhiguang – sequence: 4 givenname: Kristine surname: Yaffe fullname: Yaffe, Kristine – sequence: 5 givenname: R. Nick surname: Bryan fullname: Bryan, R. Nick – sequence: 6 givenname: Chengxuan surname: Qiu fullname: Qiu, Chengxuan – sequence: 7 givenname: Lenore J. surname: Launer fullname: Launer, Lenore J. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39081995$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVkstuEzEYhS3UipbSF2CBvGTRCb5kJjYbVFUUKrWqVLq3PPbvxDBjB18i5cV4vk6aUJXV78vnc47k8w4dhRgAoQ-UzDgX8rNLFsYZI4zPKKWkbfkbdMoE5Q2XVB69Wp-g85x_EUKYlLRbiLfohEsiqJTtKfr7EyyEotMW97DSGx_TBe6T9qGxkPwGLA5QUywprlfeYKdNiQnrYPcUziVVU2oCPG1Gbwfv4Au-xEMMS1-q9UEPB_Tu4Qbn2jd5Ot7i6HBZATYxxbCz16nANJLPv7GFDQxxPU7JdrLbWMMSa1uHkvHz6_fo2Okhw_lhnqHH62-PVz-a2_vvN1eXt43hjJVGzp2hwFrBaM9bJ1rBibHcGSALrXuyIH0nNZ_33AnJF1KDJEbPGZWGy5bxM_R1L7uu_QjWTHmSHtQ6-XGKrKL26v-b4FdqGTeKUibajslJ4dNBIcU_FXJRo88GhkEHiDUrTkTHBZt37YR-fG324vLvsyaA7QGTYs4J3AtCidqVQj2XQu1KoQ6l4E9QDLAp |
| Cites_doi | 10.3109/07853890.2015.1131327 10.1212/WNL.0000000000000867 10.1212/01.WNL.0000110315.26026.EF 10.2147/NDT.S90674 10.1037/a0013487 10.1016/j.neuron.2006.11.025 10.1371/journal.pone.0122138 10.3233/JAD-2012-120697 10.1111/j.1460-9568.2004.03720.x 10.1016/j.neuroimage.2010.03.004 10.1097/JES.0b013e3181e373a2 10.1016/S0169-328X(00)00246-1 10.1111/j.1365-2826.2012.02327.x 10.1016/S0092-8674(03)00035-7 10.1093/eurheartj/ehz100 10.1093/ntr/ntu151 10.1179/1476830511Y.0000000011 10.1001/jamanetworkopen.2021.5153 10.1001/jama.289.19.2560 10.1016/j.nicl.2018.02.032 10.1161/CIR.0000000000000440 10.1371/journal.pone.0107413 10.1002/hbm.21113 10.1007/s11682-018-0025-8 10.1016/j.neures.2009.05.010 10.1016/j.neurobiolaging.2018.06.012 10.3390/brainsci10040195 10.3389/fmed.2019.00321 10.1016/0895-4356(88)90080-7 10.1371/journal.pone.0010099 10.1001/jamaneurol.2013.4781 10.1001/jama.2017.3090 10.1002/hipo.22197 10.1523/JNEUROSCI.6251-09.2010 10.1111/j.1472-8206.2010.00912.x 10.1371/journal.pone.0035217 10.1080/13803395.2018.1442815 10.1016/j.ypmed.2021.106731 10.1016/j.neurobiolaging.2018.10.021 10.1093/gerona/glq152 10.1038/s41598-018-36419-8 10.1161/STROKEAHA.113.001447 10.2337/dc11-S062 10.1523/JNEUROSCI.1592-15.2015 10.1038/s41598-019-45976-5 10.1038/ijo.2016.168 10.1001/jamapsychiatry.2015.2468 10.1017/S0033291796003510 10.3389/fnagi.2014.00069 10.1093/braincomms/fcaa176 |
| ContentType | Journal Article |
| Copyright | Copyright © 2023 Zhang, Meirelles, Li, Yaffe, Bryan, Qiu and Launer. Copyright © 2023 Zhang, Meirelles, Li, Yaffe, Bryan, Qiu and Launer. 2023 Zhang, Meirelles, Li, Yaffe, Bryan, Qiu and Launer |
| Copyright_xml | – notice: Copyright © 2023 Zhang, Meirelles, Li, Yaffe, Bryan, Qiu and Launer. – notice: Copyright © 2023 Zhang, Meirelles, Li, Yaffe, Bryan, Qiu and Launer. 2023 Zhang, Meirelles, Li, Yaffe, Bryan, Qiu and Launer |
| DBID | AAYXX CITATION NPM 7X8 5PM |
| DOI | 10.3389/frdem.2023.1110553 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2813-3919 |
| ExternalDocumentID | PMC11285629 39081995 10_3389_frdem_2023_1110553 |
| Genre | Journal Article |
| GroupedDBID | 9T4 AAFWJ AAYXX AFPKN ALMA_UNASSIGNED_HOLDINGS CITATION GROUPED_DOAJ M~E PGMZT RPM EIHBH NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c322t-94fc1e25821b35f85830cd3fce07aab070b69a34b3f89379ae90ca4219c39523 |
| ISICitedReferencesCount | 5 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001575654500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2813-3919 |
| IngestDate | Thu Aug 21 18:34:00 EDT 2025 Thu Oct 02 10:15:19 EDT 2025 Thu Jan 02 22:37:02 EST 2025 Sat Nov 29 03:46:49 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | sedentary time longitudinal brain volume biomarkers middle-aged |
| Language | English |
| License | Copyright © 2023 Zhang, Meirelles, Li, Yaffe, Bryan, Qiu and Launer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c322t-94fc1e25821b35f85830cd3fce07aab070b69a34b3f89379ae90ca4219c39523 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Aging and Risk Factors for Dementia, a section of the journal Frontiers in Dementia Reviewed by: Alan W. J. Morris, University of Colorado Anschutz Medical Campus, United States; Angel Golimstok, Italian Hospital of Buenos Aires, Argentina Edited by: Zoe Arvanitakis, Rush University, United States |
| OpenAccessLink | http://dx.doi.org/10.3389/frdem.2023.1110553 |
| PMID | 39081995 |
| PQID | 3086382465 |
| PQPubID | 23479 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_11285629 proquest_miscellaneous_3086382465 pubmed_primary_39081995 crossref_primary_10_3389_frdem_2023_1110553 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-03-13 |
| PublicationDateYYYYMMDD | 2023-03-13 |
| PublicationDate_xml | – month: 03 year: 2023 text: 2023-03-13 day: 13 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in dementia |
| PublicationTitleAlternate | Front Dement |
| PublicationYear | 2023 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Gasquoine (B18) 2018; 40 Liu (B34) 2016; 12 Sato (B41) 2009; 65 Giorgio (B20) 2010; 51 Erickson (B16) 2010; 30 Wanders (B46) 2021 Beekman (B5) 1997; 27 Shimada (B43) 2014 Cox (B13) 2019; 40 Amoureux (B3) 2012; 26 Adcock (B1) 2020; 6 Pikula (B38) 2013; 44 Chan (B10) 2018; 70 Chang (B11) 2010 Haight (B23) 2018; 18 Burzynska (B9) 2014; 9 Launer (B32) 2015; 10 Wanner (B47) 2017; 41 Friedman (B17) 1988; 41 Takeuchi (B44) 2020; 14 Bekinschtein (B6) 2007; 53 Raz (B39) 2009; 23 Weinstein (B48) 2014; 71 Ho (B25) 2011; 32 Barha (B4) 2019; 74 Maioli (B35) 2012; 32 Jack (B27) 2004; 62 Miyamoto (B36) 2015; 35 Brown (B7) 2014; 83 Egan (B15) 2003; 112 (B2) 2011 Hayes (B24) 2018 Driscoll (B14) 2012; 7 Gejl (B19) 2019; 9 Chobanian (B12) 2003; 289 Golden (B21) 2010; 5 Kramer (B31) 2021; 4 Gottesman (B22) 2017; 317 Xia (B49) 2019 Schmitt (B42) 2016; 48 Kenny (B29) 2000; 85 Owen (B37) 2010; 38 Hoang (B26) 2016; 73 Jamal (B28) 2015; 17 Young (B51) 2016; 134 Sánchez-Villegas (B40) 2011; 14 Li (B33) 2020 Korol (B30) 2013; 23 Yamada-Goto (B50) 2012; 24 Vaynman (B45) 2004; 20 Brown (B8) 2020 |
| References_xml | – volume: 48 start-page: 42 year: 2016 ident: B42 article-title: in sleep, insomnia, and sleep deprivation publication-title: Ann. Med doi: 10.3109/07853890.2015.1131327 – volume: 83 start-page: 1345 year: 2014 ident: B7 article-title: Influence of BDNF Val66Met on the relationship between physical activity and brain volume publication-title: AAN doi: 10.1212/WNL.0000000000000867 – volume: 62 start-page: 591 year: 2004 ident: B27 article-title: Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD publication-title: Neurology doi: 10.1212/01.WNL.0000110315.26026.EF – volume: 12 start-page: 453 year: 2016 ident: B34 article-title: A voxel-based morphometric study of age- and sex-related changes in white matter volume in the normal aging brain publication-title: Neuropsychiatr. Dis. Treat doi: 10.2147/NDT.S90674 – volume: 23 start-page: 105 year: 2009 ident: B39 article-title: Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE and hypertension publication-title: Neuropsychology doi: 10.1037/a0013487 – volume: 53 start-page: 261 year: 2007 ident: B6 article-title: Persistence of long-term memory storage requires a late protein synthesis-and BDNF-dependent phase in the hippocampus publication-title: Neuron doi: 10.1016/j.neuron.2006.11.025 – volume: 10 start-page: e0122138 year: 2015 ident: B32 article-title: Vascular factors and multiple measures of early brain health: CARDIA brain MRI study publication-title: PLoS ONE doi: 10.1371/journal.pone.0122138 – volume: 32 start-page: 341 year: 2012 ident: B35 article-title: Combination of apolipoprotein E4 and high carbohydrate diet reduces hippocampal BDNF and Arc levels and impairs memory in young mice publication-title: J. Alzheimer's Dis doi: 10.3233/JAD-2012-120697 – volume: 20 start-page: 2580 year: 2004 ident: B45 article-title: Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition publication-title: Eur. J. Neurosci doi: 10.1111/j.1460-9568.2004.03720.x – volume: 51 start-page: 943 year: 2010 ident: B20 article-title: Age-related changes in gray and white matter structure throughout adulthood publication-title: Neuroimage doi: 10.1016/j.neuroimage.2010.03.004 – volume: 38 start-page: 105 year: 2010 ident: B37 article-title: Too much sitting: the population-health science of sedentary behavior publication-title: Exerc. Sport Sci. Rev doi: 10.1097/JES.0b013e3181e373a2 – volume: 85 start-page: 234 year: 2000 ident: B29 article-title: Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus publication-title: Mol. Brain Res doi: 10.1016/S0169-328X(00)00246-1 – volume: 24 start-page: 1120 year: 2012 ident: B50 article-title: Impairment of fear-conditioning responses and changes of brain neurotrophic factors in diet-induced obese mice publication-title: J. Neuroendocrinol doi: 10.1111/j.1365-2826.2012.02327.x – volume: 112 start-page: 257 year: 2003 ident: B15 article-title: The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function publication-title: Cell doi: 10.1016/S0092-8674(03)00035-7 – volume: 40 start-page: 2290 year: 2019 ident: B13 article-title: Associations between vascular risk factors and brain MRI incides in UK Biobank publication-title: Eur. Heart J doi: 10.1093/eurheartj/ehz100 – volume: 17 start-page: 323 year: 2015 ident: B28 article-title: Association between smoking, nocotine dependence, and BDNF Val66Met polymorphism with BDNF concentrations in serum publication-title: Nicotine Tob. Res doi: 10.1093/ntr/ntu151 – volume: 14 start-page: 195 year: 2011 ident: B40 article-title: The effect of the Mediterranean diet on plasma brain-derived neurotrophic factor (BDNF) levels: the PREDIMED-NAVARRA randomized trial publication-title: Nutr. Neurosci doi: 10.1179/1476830511Y.0000000011 – volume: 4 start-page: e215153 year: 2021 ident: B31 article-title: How to better study the associations between physical activity, exercise, and cognitive and brain health publication-title: JAMA Netw. Open doi: 10.1001/jamanetworkopen.2021.5153 – volume: 289 start-page: 2560 year: 2003 ident: B12 article-title: The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report publication-title: JAMA doi: 10.1001/jama.289.19.2560 – volume: 18 start-page: 753 year: 2018 ident: B23 article-title: White matter microstructure, white matter lesions, and hypertension: an examination of early surrogate markers of vascular-realted brain change in midlife publication-title: NeuroImage Clin doi: 10.1016/j.nicl.2018.02.032 – volume: 134 start-page: e262 year: 2016 ident: B51 article-title: Sedentary behavior and cardiovascular morbidity and mortality: a science advisory from the American Heart Association publication-title: Circulation doi: 10.1161/CIR.0000000000000440 – volume: 9 start-page: e107413 year: 2014 ident: B9 article-title: Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults publication-title: PLoS ONE doi: 10.1371/journal.pone.0107413 – volume: 32 start-page: 1371 year: 2011 ident: B25 article-title: The effects of physical activity, education, and body mass index on the aging brain publication-title: Hum. Brain Mapp doi: 10.1002/hbm.21113 – volume: 14 start-page: 806 year: 2020 ident: B44 article-title: Effect of the interaction between BDNF Val66Met polymorphism and daily physical activity on mean diffusivity publication-title: Brain Imaging Behav doi: 10.1007/s11682-018-0025-8 – volume: 65 start-page: 71 year: 2009 ident: B41 article-title: White matter activated glial cells produce BDNF in a stroke model of monkeys publication-title: Neurosci. Res doi: 10.1016/j.neures.2009.05.010 – volume: 70 start-page: 180 year: 2018 ident: B10 article-title: Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2018.06.012 – year: 2020 ident: B8 article-title: The BDNF Val66Met polymorphism modulates resilience of neurological functioning to brain ageing and dementia: a narrative review publication-title: Brain Sci doi: 10.3390/brainsci10040195 – volume: 6 start-page: 321 year: 2020 ident: B1 article-title: Effects of an in-home multicomponent exergame training on physical functions, cognition, and brain volume of older adults: a randomized controlled trial publication-title: Font. Med doi: 10.3389/fmed.2019.00321 – volume: 41 start-page: 1105 year: 1988 ident: B17 article-title: CARDIA: study design, recruitment, and some characteristics of the examined subjects publication-title: J. Clin. Epidemiol doi: 10.1016/0895-4356(88)90080-7 – volume: 5 start-page: e10099 year: 2010 ident: B21 article-title: Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging publication-title: PLoS ONE doi: 10.1371/journal.pone.0010099 – volume: 71 start-page: 55 year: 2014 ident: B48 article-title: Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2013.4781 – volume: 317 start-page: 1443 year: 2017 ident: B22 article-title: Association between midlife vascular risk factors and estimated brain amyloid deposition publication-title: JAMA doi: 10.1001/jama.2017.3090 – volume: 23 start-page: 1125 year: 2013 ident: B30 article-title: Use it and boost it with physical and mental activity publication-title: Hippocampus doi: 10.1002/hipo.22197 – volume: 30 start-page: 5368 year: 2010 ident: B16 article-title: Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume publication-title: J. Neurosci doi: 10.1523/JNEUROSCI.6251-09.2010 – volume: 26 start-page: 227 year: 2012 ident: B3 article-title: Vascular BDNF expression and oxidative stress during aging and the development of chronic hypertension publication-title: Fundam. Clin. Pharmacol doi: 10.1111/j.1472-8206.2010.00912.x – volume: 7 start-page: e35217 year: 2012 ident: B14 article-title: Plasma BDNF is associated with age-related white matter atrophy but not with cognitive function in older, non-demented adults publication-title: PLoS ONE doi: 10.1371/journal.pone.0035217 – volume: 40 start-page: 874 year: 2018 ident: B18 article-title: Effects of physical activity on delayed memory measures in randomized controlled trials with nonclinical older, mild cognitive impairment dementia participants publication-title: J. Clin. Exp. Neuropsychol doi: 10.1080/13803395.2018.1442815 – year: 2021 ident: B46 article-title: Association between sedentary time and cognitive function: a focus on different domains of sedentary behavior publication-title: Prev. Med doi: 10.1016/j.ypmed.2021.106731 – volume: 74 start-page: 161 year: 2019 ident: B4 article-title: Sex-dependent effect of the BDNF Val66Met polymorphism on executive functioning and processing speed in older adults: evidence from the Health ABC study publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2018.10.021 – start-page: 1369 year: 2010 ident: B11 article-title: The effect of midlife physical activity on cognitive function among older adults: AGES—Reykjavik Study publication-title: J. Gerontol. A Biol. Sci. Med. Sci doi: 10.1093/gerona/glq152 – year: 2019 ident: B49 article-title: Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism publication-title: Sci. Rep doi: 10.1038/s41598-018-36419-8 – volume: 44 start-page: 2768 year: 2013 ident: B38 article-title: Serum brain-derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury: Framingham Study publication-title: Stroke doi: 10.1161/STROKEAHA.113.001447 – year: 2011 ident: B2 article-title: Diagnosis and classification of diabetes mellitus publication-title: Diab Care. doi: 10.2337/dc11-S062 – volume: 35 start-page: 14002 year: 2015 ident: B36 article-title: Astrocytes promote oligodendrogenesis after white matter damage via brain-derived neurotrophic factor publication-title: J. Neurosci doi: 10.1523/JNEUROSCI.1592-15.2015 – volume: 9 start-page: 1 year: 2019 ident: B19 article-title: Associations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategy publication-title: Sci. Rep doi: 10.1038/s41598-019-45976-5 – volume: 41 start-page: 186 year: 2017 ident: B47 article-title: Associations between self-reported and objectively measured physical activity, sedentary behvaior and overweight/obesity in NHANES 2003–2006 publication-title: Int. J. Obes doi: 10.1038/ijo.2016.168 – volume: 73 start-page: 73 year: 2016 ident: B26 article-title: Effect of early adult patterns of physical activity and television viewing on midlife cognitive function publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2015.2468 – year: 2018 ident: B24 publication-title: Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach. – volume: 27 start-page: 231 year: 1997 ident: B5 article-title: Criterion validity of the center for epidemiology studies depression scale (CES-D): restuls from a community-based sample of older subjects in the netherlands publication-title: Psychol. Med doi: 10.1017/S0033291796003510 – year: 2014 ident: B43 article-title: A large, cross-sectional observational study of serum BDNF, cognitive function, and mild cognitive impairment in the elderly publication-title: Front. Aging Neurosci doi: 10.3389/fnagi.2014.00069 – year: 2020 ident: B33 article-title: The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages publication-title: Brain Commun. doi: 10.1093/braincomms/fcaa176 |
| SSID | ssj0002991678 |
| Score | 2.2477875 |
| Snippet | Brain-derived neurotrophic factor levels are higher in those who are physically active and lower in people with cognitive dysfunction. This study investigated... |
| SourceID | pubmedcentral proquest pubmed crossref |
| SourceType | Open Access Repository Aggregation Database Index Database |
| StartPage | 1110553 |
| SubjectTerms | Dementia |
| Title | Sedentary behavior, brain-derived neurotrophic factor and brain structure in midlife: A longitudinal brain MRI sub-study of the coronary artery risk development in young adults study |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/39081995 https://www.proquest.com/docview/3086382465 https://pubmed.ncbi.nlm.nih.gov/PMC11285629 |
| Volume | 2 |
| WOSCitedRecordID | wos001575654500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals (ODIN) customDbUrl: eissn: 2813-3919 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002991678 issn: 2813-3919 databaseCode: DOA dateStart: 20220101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2813-3919 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002991678 issn: 2813-3919 databaseCode: M~E dateStart: 20220101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3LjtMwFLU6A0KzQSBe5VEZiV1JSe2kcdiNEAgkOiDoomITJU48jdRJqqatZjZ8Fn_BP3Gv7TzaAQkWbKImcZw05-T6de-5hLwIxil8NSlzxkJyx4tDz4knXurI2I0TxRUu_ehkE8HZmZjPw8-93s86Fma3DIpCXF6Gq_8KNRwDsDF09h_gbiqFA_AbQIctwA7bvwL-a4axt-gMV4fg42tMMBWEk8ID7HDBHyU5NutytcilTbmjVxF0qaHRlMWVBdi5yNNlrmwE-7LE9EbbVKfSMoWnXz4Mq23iVLU6NfZkJeoi4CNoj9Er48Cetv5JWPEV2hmj_1F1VG7rlKEorIBpuo27rnZqalqQZpZ7vm3JPc3Aei9tCu9PVbnOy9ad-aN2Wvi2yM_hivPG1MVKZa2psx4Gdg6EcXQCMyGso0zbSibG3OGhtb7WsLOOYQaT7vpGlviw0YBBOmquqjX8mRHWPvpNYXjLqwvNGB5iL8pkBj2Q6q5PHZEbLPBD9DCcfm-n_Bj2xQNhQrfwrq-u3_OE3Kpr2e8pXRv-HHrxdrpFszvkth3P0FPDw7uklxX3yI-Gg7Tm4Eu6x0DaZSA1DKTAQFOKNgyksGMZ-Jqe0i7_bFHgH234R0tFgX-05h81_KPIP9rhH1ar-UcN_6i--j6ZvXs7e_PesQlCHAnt0MYJPSXHGcNY74T7SviCuzLlSmZuEMcJtGbJJIy5l3CF3XLUoXdl7EEjLXnoM_6AHBdlkT0ilKUT6QmVoHqSlzEVMzeGrn-aBmDimKf6ZFhjEa2MDEwEw2cEMdIgRghiZEHsk-c1XBFYa1yCi4us3FYRdwU0eMyb-H3y0MDX1Ffj3idiD9imACrB758p8oVWhIdBk4CBTPj4j5U-ISfth_OUHAOM2TNyU-42ebUekKNgLgZ6PmqgOfsLDA3bvg |
| linkProvider | ISSN International Centre |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sedentary+behavior%2C+brain-derived+neurotrophic+factor+and+brain+structure+in+midlife%3A+A+longitudinal+brain+MRI+sub-study+of+the+coronary+artery+risk+development+in+young+adults+study&rft.jtitle=Frontiers+in+dementia&rft.au=Zhang%2C+Xuan&rft.au=Meirelles%2C+Osorio+D&rft.au=Li%2C+Zhiguang&rft.au=Yaffe%2C+Kristine&rft.date=2023-03-13&rft.eissn=2813-3919&rft.volume=2&rft.spage=1110553&rft_id=info:doi/10.3389%2Ffrdem.2023.1110553&rft_id=info%3Apmid%2F39081995&rft.externalDocID=39081995 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2813-3919&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2813-3919&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2813-3919&client=summon |