Optic Nerve Topography in Multiple Sclerosis Diagnosis: The Utility of Visual Evoked Potentials

To assess the added value of the optic nerve region (by using visual evoked potentials [VEPs]) to the current diagnostic criteria. From the Barcelona clinically isolated syndrome (CIS) cohort, patients with complete information to assess dissemination in space (DIS), the optic nerve region, and diss...

Full description

Saved in:
Bibliographic Details
Published in:Neurology Vol. 96; no. 4; p. e482
Main Authors: Vidal-Jordana, Angela, Rovira, Alex, Arrambide, Georgina, Otero-Romero, Susana, Río, Jordi, Comabella, Manuel, Nos, Carlos, Castilló, Joaquin, Galan, Ingrid, Cabello, Sergio, Moncho, Dulce, Rahnama, Kimia, Thonon, Vanessa, Rodríguez-Acevedo, Breogan, Zabalza, Ana, Midaglia, Luciana, Auger, Cristina, Sastre-Garriga, Jaume, Montalban, Xavier, Tintoré, Mar
Format: Journal Article
Language:English
Published: United States 26.01.2021
Subjects:
Adult
Cohort Studies
Evoked Potentials, Visual - physiology
Female
Follow-Up Studies
Humans
Male
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - physiopathology
Neurologic Examination - methods
Optic Nerve - diagnostic imaging
Optic Nerve - physiopathology
Optic Neuritis - diagnostic imaging
Optic Neuritis - physiopathology
Retrospective Studies
Young Adult
ISSN:1526-632X, 1526-632X
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract To assess the added value of the optic nerve region (by using visual evoked potentials [VEPs]) to the current diagnostic criteria. From the Barcelona clinically isolated syndrome (CIS) cohort, patients with complete information to assess dissemination in space (DIS), the optic nerve region, and dissemination in time at baseline (n = 388) were selected. Modified DIS (modDIS) criteria were constructed by adding the optic nerve to the current DIS regions. The DIS and modDIS criteria were evaluated with univariable Cox proportional hazard regression analyses with the time to the second attack as the outcome. A subset of these patients who had at least 10 years of follow-up or a second attack occurring within 10 years (n = 151) were selected to assess the diagnostic performance. The analyses were also performed according to CIS topography (optic neuritis vs non-optic neuritis). The addition of the optic nerve as a fifth region improved the diagnostic performance by slightly increasing the accuracy (2017 DIS 75.5%, modDIS 78.1%) and the sensitivity (2017 DIS 79.2%, modDIS 82.3%) without lowering the specificity (2017 DIS 52.4%, modDIS 52.4%). When the analysis was conducted according to CIS topography, the modDIS criteria performed similarly in both optic neuritis and non-optic neuritis CIS. The addition of the optic nerve, assessed by VEP, as a fifth region in the current DIS criteria slightly improves the diagnostic performance because it increases sensitivity without losing specificity.
AbstractList To assess the added value of the optic nerve region (by using visual evoked potentials [VEPs]) to the current diagnostic criteria. From the Barcelona clinically isolated syndrome (CIS) cohort, patients with complete information to assess dissemination in space (DIS), the optic nerve region, and dissemination in time at baseline (n = 388) were selected. Modified DIS (modDIS) criteria were constructed by adding the optic nerve to the current DIS regions. The DIS and modDIS criteria were evaluated with univariable Cox proportional hazard regression analyses with the time to the second attack as the outcome. A subset of these patients who had at least 10 years of follow-up or a second attack occurring within 10 years (n = 151) were selected to assess the diagnostic performance. The analyses were also performed according to CIS topography (optic neuritis vs non-optic neuritis). The addition of the optic nerve as a fifth region improved the diagnostic performance by slightly increasing the accuracy (2017 DIS 75.5%, modDIS 78.1%) and the sensitivity (2017 DIS 79.2%, modDIS 82.3%) without lowering the specificity (2017 DIS 52.4%, modDIS 52.4%). When the analysis was conducted according to CIS topography, the modDIS criteria performed similarly in both optic neuritis and non-optic neuritis CIS. The addition of the optic nerve, assessed by VEP, as a fifth region in the current DIS criteria slightly improves the diagnostic performance because it increases sensitivity without losing specificity.
To assess the added value of the optic nerve region (by using visual evoked potentials [VEPs]) to the current diagnostic criteria.OBJECTIVETo assess the added value of the optic nerve region (by using visual evoked potentials [VEPs]) to the current diagnostic criteria.From the Barcelona clinically isolated syndrome (CIS) cohort, patients with complete information to assess dissemination in space (DIS), the optic nerve region, and dissemination in time at baseline (n = 388) were selected. Modified DIS (modDIS) criteria were constructed by adding the optic nerve to the current DIS regions. The DIS and modDIS criteria were evaluated with univariable Cox proportional hazard regression analyses with the time to the second attack as the outcome. A subset of these patients who had at least 10 years of follow-up or a second attack occurring within 10 years (n = 151) were selected to assess the diagnostic performance. The analyses were also performed according to CIS topography (optic neuritis vs non-optic neuritis).METHODSFrom the Barcelona clinically isolated syndrome (CIS) cohort, patients with complete information to assess dissemination in space (DIS), the optic nerve region, and dissemination in time at baseline (n = 388) were selected. Modified DIS (modDIS) criteria were constructed by adding the optic nerve to the current DIS regions. The DIS and modDIS criteria were evaluated with univariable Cox proportional hazard regression analyses with the time to the second attack as the outcome. A subset of these patients who had at least 10 years of follow-up or a second attack occurring within 10 years (n = 151) were selected to assess the diagnostic performance. The analyses were also performed according to CIS topography (optic neuritis vs non-optic neuritis).The addition of the optic nerve as a fifth region improved the diagnostic performance by slightly increasing the accuracy (2017 DIS 75.5%, modDIS 78.1%) and the sensitivity (2017 DIS 79.2%, modDIS 82.3%) without lowering the specificity (2017 DIS 52.4%, modDIS 52.4%). When the analysis was conducted according to CIS topography, the modDIS criteria performed similarly in both optic neuritis and non-optic neuritis CIS.RESULTSThe addition of the optic nerve as a fifth region improved the diagnostic performance by slightly increasing the accuracy (2017 DIS 75.5%, modDIS 78.1%) and the sensitivity (2017 DIS 79.2%, modDIS 82.3%) without lowering the specificity (2017 DIS 52.4%, modDIS 52.4%). When the analysis was conducted according to CIS topography, the modDIS criteria performed similarly in both optic neuritis and non-optic neuritis CIS.The addition of the optic nerve, assessed by VEP, as a fifth region in the current DIS criteria slightly improves the diagnostic performance because it increases sensitivity without losing specificity.CONCLUSIONThe addition of the optic nerve, assessed by VEP, as a fifth region in the current DIS criteria slightly improves the diagnostic performance because it increases sensitivity without losing specificity.
Author Nos, Carlos
Vidal-Jordana, Angela
Thonon, Vanessa
Rovira, Alex
Moncho, Dulce
Auger, Cristina
Montalban, Xavier
Comabella, Manuel
Sastre-Garriga, Jaume
Zabalza, Ana
Arrambide, Georgina
Cabello, Sergio
Galan, Ingrid
Rodríguez-Acevedo, Breogan
Midaglia, Luciana
Tintoré, Mar
Rahnama, Kimia
Río, Jordi
Otero-Romero, Susana
Castilló, Joaquin
Author_xml – sequence: 1
  givenname: Angela
  surname: Vidal-Jordana
  fullname: Vidal-Jordana, Angela
  email: avidal@cem-cat.org
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada. avidal@cem-cat.org
– sequence: 2
  givenname: Alex
  surname: Rovira
  fullname: Rovira, Alex
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 3
  givenname: Georgina
  surname: Arrambide
  fullname: Arrambide, Georgina
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 4
  givenname: Susana
  surname: Otero-Romero
  fullname: Otero-Romero, Susana
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 5
  givenname: Jordi
  surname: Río
  fullname: Río, Jordi
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 6
  givenname: Manuel
  surname: Comabella
  fullname: Comabella, Manuel
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 7
  givenname: Carlos
  surname: Nos
  fullname: Nos, Carlos
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 8
  givenname: Joaquin
  surname: Castilló
  fullname: Castilló, Joaquin
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 9
  givenname: Ingrid
  surname: Galan
  fullname: Galan, Ingrid
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 10
  givenname: Sergio
  surname: Cabello
  fullname: Cabello, Sergio
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 11
  givenname: Dulce
  surname: Moncho
  fullname: Moncho, Dulce
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 12
  givenname: Kimia
  surname: Rahnama
  fullname: Rahnama, Kimia
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 13
  givenname: Vanessa
  surname: Thonon
  fullname: Thonon, Vanessa
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 14
  givenname: Breogan
  surname: Rodríguez-Acevedo
  fullname: Rodríguez-Acevedo, Breogan
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 15
  givenname: Ana
  surname: Zabalza
  fullname: Zabalza, Ana
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 16
  givenname: Luciana
  surname: Midaglia
  fullname: Midaglia, Luciana
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 17
  givenname: Cristina
  surname: Auger
  fullname: Auger, Cristina
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 18
  givenname: Jaume
  surname: Sastre-Garriga
  fullname: Sastre-Garriga, Jaume
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 19
  givenname: Xavier
  surname: Montalban
  fullname: Montalban, Xavier
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
– sequence: 20
  givenname: Mar
  surname: Tintoré
  fullname: Tintoré, Mar
  organization: From the Servicio de Neurología-Neuroinmunología (A V.-J., G.A., S.O.-R., J.R., M.C., C.N., J.C., I.G., S.C., B.R.-A., A.Z., L.M., J.S.-G., X.M., M.T.), Centro de Esclerosis Múltiple de Catalunya (Cemcat), Sección de Neuroradiologia (A.R., C.A.), Servei de Radiologia, Servicio de Medicina Preventiva y Epidemiologia (S.O.-R.), and Servicio de Neurofisiología Clínica (D.M., K.R., V.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital. University of Toronto, Ontario, Canada
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33328323$$D View this record in MEDLINE/PubMed
BookMark eNpNkMtOwzAURC1URB_wBwh5ySbFryYxO1TKQyotEi2wi2znpjW4cYiTSv17igDBbM4sjmYxfdQpfQkInVIypIyyi5fZdEj-Qinn8gD16IjFUczZa-df76J-CG97acQSeYS6nHOWcsZ7KJtXjTV4BvUW8MJXflWrar3DtsQPrWts5QA_GQe1Dzbga6tW5Ve7xIs14GVjnW122Bf42YZWOTzZ-nfI8aNvoGyscuEYHRZ7wMkPB2h5M1mM76Lp_PZ-fDWNDGdMRFTHRvNUFErxPBfMpDknUquk0IlUSZpoqpUkoqAQCwEiT43I9YgTojVwqdkAnX_vVrX_aCE02cYGA86pEnwbMiYSIglnMt6rZz9qqzeQZ1VtN6reZb-nsE-NVWdz
CitedBy_id crossref_primary_10_1016_S1474_4422_22_00334_9
crossref_primary_10_1186_s12886_022_02595_5
crossref_primary_10_1212_WNL_0000000000207805
crossref_primary_10_1016_j_msard_2022_104116
crossref_primary_10_1177_13524585231209016
crossref_primary_10_1056_NEJMclde2300812
crossref_primary_10_1212_cont_0000000000001560
crossref_primary_10_1016_S1474_4422_25_00275_3
crossref_primary_10_1212_WNL_0000000000013016
crossref_primary_10_1016_S0140_6736_23_01473_3
crossref_primary_10_1007_s00415_022_11488_y
crossref_primary_10_1016_S1474_4422_25_00270_4
crossref_primary_10_1097_WNO_0000000000002017
crossref_primary_10_1007_s00415_024_12801_7
crossref_primary_10_1007_s00415_023_11920_x
crossref_primary_10_1016_j_clinph_2022_02_013
crossref_primary_10_1002_ana_27145
crossref_primary_10_1002_acn3_51632
crossref_primary_10_1016_j_clinph_2024_02_020
crossref_primary_10_1016_j_lanepe_2024_100978
crossref_primary_10_1007_s00415_025_13036_w
crossref_primary_10_1167_iovs_65_13_50
crossref_primary_10_1212_NXI_0000000000001135
crossref_primary_10_1212_WNL_0000000000011344
crossref_primary_10_1212_WNL_0000000000207913
crossref_primary_10_46518_kjnmd_2021_13_2_21
crossref_primary_10_1055_a_2251_0394
crossref_primary_10_1080_14737175_2021_1957832
crossref_primary_10_1016_j_msard_2023_104503
crossref_primary_10_1007_s00415_025_13395_4
crossref_primary_10_1177_13524585231225848
crossref_primary_10_1177_20552173251340957
crossref_primary_10_1212_WNL_0000000000210274
crossref_primary_10_1055_a_2034_4371
crossref_primary_10_1002_acn3_52170
crossref_primary_10_1016_j_nic_2024_03_002
crossref_primary_10_1186_s12886_023_03044_7
crossref_primary_10_1016_j_ejpn_2021_12_005
crossref_primary_10_1016_j_nic_2024_03_001
crossref_primary_10_1016_S1474_4422_22_00187_9
crossref_primary_10_1016_j_jns_2023_120669
crossref_primary_10_1212_WNL_0000000000209677
crossref_primary_10_1007_s00415_024_12335_y
crossref_primary_10_1016_j_ejpn_2022_08_006
crossref_primary_10_1212_NXI_0000000000200458
ContentType Journal Article
Copyright Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
Copyright_xml – notice: Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
DBID CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1212/WNL.0000000000011339
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Medicine
EISSN 1526-632X
ExternalDocumentID 33328323
Genre Journal Article
Observational Study
GroupedDBID ---
-~X
.XZ
.Z2
01R
0R~
123
1J1
29N
354
3PY
4Q1
4Q2
4Q3
53G
5RE
5VS
6PF
77Y
AAAXR
AAGIX
AAHPQ
AAIQE
AAJCS
AAMOA
AAMTA
AAQKA
AARTV
AASCR
AASOK
AASXQ
AAWTL
AAXQO
AAYEP
ABBLC
ABIVO
ABJNI
ABOCM
ABVCZ
ABXYN
ABZZY
ACDDN
ACGFS
ACIJW
ACILI
ACLDA
ACOAL
ACWRI
ACXJB
ACZKN
ADGGA
AE6
AEBDS
AENEX
AFDTB
AFEXH
AFNMH
AFUWQ
AGINI
AHOMT
AHQNM
AHQVU
AHVBC
AIJEX
AJCLO
AKCTQ
AKULP
AKWKN
ALMA_UNASSIGNED_HOLDINGS
AMJPA
AMKUR
AMNEI
AOHHW
BOYCO
BQLVK
BYPQX
C45
CGR
CS3
CUY
CVF
DIWNM
DU5
E.X
EBS
ECM
EIF
EJD
ERAAH
EX3
F2K
F2L
F2M
F2N
F5P
FCALG
GQDEL
HZ~
IKYAY
IN~
IPNFZ
JF7
KD2
KMI
L-C
L7B
N9A
NPM
N~7
N~B
O9-
OAG
OAH
OBH
ODMTH
OHH
OHYEH
OL1
OLB
OLH
OLU
OLV
OLY
OLZ
OPX
OVD
OVDNE
OVIDH
OVLEI
OWU
OWV
OWW
OWX
OWY
OWZ
OXXIT
P2P
RIG
RLZ
RXW
SJN
TEORI
V2I
VVN
W3M
WH7
WOQ
WOW
XSW
XXN
XYM
XYN
YBU
YCJ
YFH
~9M
7X8
ABPXF
ADKSD
ADSXY
ID FETCH-LOGICAL-c3224-1b6cb384faa3dd42c8d309ba7fb79a787b1ba904f1e644e4d8c4db5300bbe39b2
IEDL.DBID 7X8
ISSN 1526-632X
IngestDate Mon Sep 08 06:07:13 EDT 2025
Thu Apr 03 07:03:12 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Language English
License Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3224-1b6cb384faa3dd42c8d309ba7fb79a787b1ba904f1e644e4d8c4db5300bbe39b2
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC7905792
PMID 33328323
PQID 2470903296
PQPubID 23479
ParticipantIDs proquest_miscellaneous_2470903296
pubmed_primary_33328323
PublicationCentury 2000
PublicationDate 2021-01-26
20210126
PublicationDateYYYYMMDD 2021-01-26
PublicationDate_xml – month: 01
  year: 2021
  text: 2021-01-26
  day: 26
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Neurology
PublicationTitleAlternate Neurology
PublicationYear 2021
References 33328321 - Neurology. 2021 Jan 26;96(4):139-140
References_xml – reference: 33328321 - Neurology. 2021 Jan 26;96(4):139-140
SSID ssj0015279
Score 2.5443933
Snippet To assess the added value of the optic nerve region (by using visual evoked potentials [VEPs]) to the current diagnostic criteria. From the Barcelona...
To assess the added value of the optic nerve region (by using visual evoked potentials [VEPs]) to the current diagnostic criteria.OBJECTIVETo assess the added...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage e482
SubjectTerms Adult
Cohort Studies
Evoked Potentials, Visual - physiology
Female
Follow-Up Studies
Humans
Male
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - physiopathology
Neurologic Examination - methods
Optic Nerve - diagnostic imaging
Optic Nerve - physiopathology
Optic Neuritis - diagnostic imaging
Optic Neuritis - physiopathology
Retrospective Studies
Young Adult
Title Optic Nerve Topography in Multiple Sclerosis Diagnosis: The Utility of Visual Evoked Potentials
URI https://www.ncbi.nlm.nih.gov/pubmed/33328323
https://www.proquest.com/docview/2470903296
Volume 96
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEA6-EC--3w8ieA3bNtk28SKiu3hw64LuureSV6EI7Wp3Bf-9kzayNxHsoT2FttMvX6YzX2YQutLKJBZceWJlKAkzPCYiUCERJgh1zLuaNu18xo9JmvLJRAx9wK32ssofTmyI2lTaxcg7EUtcSCES8c30nbiuUS676ltoLKNVCq6Mk3Qlk0UWoRs1tfbgGpOYRhO_dQ7YuvOaPralC9sjhF-1X5zMZrHpb_33MbfRpncz8W2Lix20ZMtdtD7wifQ9lD0BVWicOr0jfqmmvnA1Lko88BJD_AwjYQ0tanzf6vGK-hoDrPBo5gS1X7jK8bio53Cf3mf1Zg0eVjMnPgJE76NRv_dy90B8rwWiYUozEqpYK8pZLiU1hkWaGxoIJZNcJULCrFahkiJgeWjBg7LwUTUzqkuDQClLhYoO0EpZlfYIYdG1nLFccKsFU1ZyAawqAims0Fwl7Bhd_pguAyy7BIUsbTWvs4XxjtFha_9s2hbdyCiABtiHnvxh9CnaiJz0JAhJFJ-h1Rze256jNf05K-qPiwYkcE6Hg28NSMZj
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Optic+Nerve+Topography+in+Multiple+Sclerosis+Diagnosis%3A+The+Utility+of+Visual+Evoked+Potentials&rft.jtitle=Neurology&rft.au=Vidal-Jordana%2C+Angela&rft.au=Rovira%2C+Alex&rft.au=Arrambide%2C+Georgina&rft.au=Otero-Romero%2C+Susana&rft.date=2021-01-26&rft.issn=1526-632X&rft.eissn=1526-632X&rft.volume=96&rft.issue=4&rft.spage=e482&rft_id=info:doi/10.1212%2FWNL.0000000000011339&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1526-632X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1526-632X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1526-632X&client=summon