Effects of frusemide on the urinary excretion of dopamine and 5-hydroxytryptamine in normal man

The effects of frusemide on the urinary excretion of dopamine and 5-hydroxytryptamine (5-HT) were investigated in eight healthy male subjects in a randomized, placebo-controlled, cross-over study. Frusemide produced the expected rise in urinary dopamine excretion but it did not affect 5-HT excretion...

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Bibliographic Details
Published in:British journal of clinical pharmacology Vol. 42; no. 4; p. 522
Main Authors: Li Kam Wa, T C, Freestone, S, McCrindle, J L, Samson, R R, Johnston, N R, Lee, M R
Format: Journal Article
Language:English
Published: England 01.10.1996
Subjects:
Adult
Diuretics - urine
Dopamine - urine
Furosemide - pharmacology
Humans
Male
Placebos
Serotonin - urine
ISSN:0306-5251
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Summary:The effects of frusemide on the urinary excretion of dopamine and 5-hydroxytryptamine (5-HT) were investigated in eight healthy male subjects in a randomized, placebo-controlled, cross-over study. Frusemide produced the expected rise in urinary dopamine excretion but it did not affect 5-HT excretion when compared with placebo. The lack of an effect on 5-HT excretion in man contrasts with studies in the rat which have reported a marked increase in 5-HT excretion after administration of this loop diuretic.
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ISSN:0306-5251
DOI:10.1046/j.1365-2125.1996.46120.x