The Influence of Pharmacogenetic Variants in HIV/Tuberculosis Coinfected Patients in Uganda in the SOUTH Study

Unsatisfactory treatment outcomes have been reported in patients coinfected with HIV/tuberculosis (TB). The aim of this study was to assess the influence of single-nucleotide polymorphisms (SNPs) in genes encoding for proteins involved in antitubercular drug disposition or effect. A pharmacogenetic...

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Veröffentlicht in:	Clinical pharmacology and therapeutics Jg. 106; H. 2; S. 450
Hauptverfasser:	Calcagno, Andrea, Cusato, Jessica, Sekaggya-Wiltshire, Christine, von Braun, Amrei, Motta, Ilaria, Turyasingura, Grace, Castelnuovo, Barbara, Fehr, Jan, Di Perri, Giovanni, Lamorde, Mohammed
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.08.2019
Schlagworte:	Adult Antitubercular Agents - adverse effects Antitubercular Agents - pharmacokinetics Arylamine N-Acetyltransferase - genetics Correlation of Data Female HIV Infections - epidemiology HIV Infections - genetics HIV Infections - therapy Humans Isoniazid - adverse effects Isoniazid - pharmacokinetics Liver-Specific Organic Anion Transporter 1 - genetics Male Outcome Assessment, Health Care Pharmacogenomic Variants - genetics Polymorphism, Single Nucleotide Pregnane X Receptor - genetics Rifampin - adverse effects Rifampin - pharmacokinetics Tuberculosis - drug therapy Tuberculosis - epidemiology Tuberculosis - genetics Uganda - epidemiology Uganda
ISSN:	1532-6535, 1532-6535
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