Clofazimine: an old drug for never-ending diseases

Clofazimine (CFZ), an old hydrophobic riminophenazine, has a wide range of antimycobacterial activity ranging from leprosy to nontuberculous mycobacterial diseases. CFZ has several advantages such as a favorable pharmacokinetic profile, dose-dependent side effects as well as low price. In this narra...

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Bibliographic Details
Published in:Future microbiology Vol. 15; no. 7; pp. 557 - 566
Main Authors: Riccardi, Niccolò, Giacomelli, Andrea, Canetti, Diana, Comelli, Agnese, Intini, Enrica, Gaiera, Giovanni, Diaw, Mama M, Udwadia, Zarir, Besozzi, Giorgio, Codecasa, Luigi, Biagio, Antonio Di
Format: Journal Article
Language:English
Published: Future Medicine Ltd 01.05.2020
Subjects:
clofazimine
leprosy
MDR-TB
NTM
XDR-TB
ISSN:1746-0913, 1746-0921, 1746-0921
Online Access:Get full text
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Summary:Clofazimine (CFZ), an old hydrophobic riminophenazine, has a wide range of antimycobacterial activity ranging from leprosy to nontuberculous mycobacterial diseases. CFZ has several advantages such as a favorable pharmacokinetic profile, dose-dependent side effects as well as low price. In this narrative review, we have assessed the clinical development of CFZ, starting from the potential mechanism of actions, to the spectrum of side effects and potential drug–drug interactions, highlighting its current place in therapy and future possible use in leprosy, nontuberculous mycobacterial diseases and drug-resistant tuberculosis.
Bibliography:ObjectType-Article-1
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ISSN:1746-0913
1746-0921
1746-0921
DOI:10.2217/fmb-2019-0231