Three-dimensional characterization of optical coherence tomography point spread functions with a nanoparticle-embedded phantom

We present a novel (to our knowledge) approach for measurement of the three-dimensional point spread function (PSF) of optical coherence tomography (OCT) systems using a nanoparticle-embedded phantom (NEP), toward development of standardized test methods for biophotonic imaging. The NEP comprises hi...

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Veröffentlicht in:Optics letters Jg. 35; H. 13; S. 2269
Hauptverfasser: Agrawal, Anant, Pfefer, T Joshua, Gilani, Naureen, Drezek, Rebekah
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.07.2010
Schlagworte:
Imaging, Three-Dimensional - instrumentation
Nanoshells
Phantoms, Imaging
Tomography, Optical Coherence - instrumentation
ISSN:1539-4794, 1539-4794
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Zusammenfassung:We present a novel (to our knowledge) approach for measurement of the three-dimensional point spread function (PSF) of optical coherence tomography (OCT) systems using a nanoparticle-embedded phantom (NEP), toward development of standardized test methods for biophotonic imaging. The NEP comprises highly reflective plasmonic nanoparticles, homogeneously distributed in a transparent silicone matrix. OCT image volumes were analyzed to characterize PSFs in axial and lateral directions at a variety of locations in the NEP. Results indicate submicrometer agreement with conventional approaches to measure dimensions of the PSF. The NEP offers a robust approach for validating and comparing imaging performance of OCT devices.
Bibliographie:ObjectType-Article-1
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ISSN:1539-4794
1539-4794
DOI:10.1364/OL.35.002269