Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease

Accumulation of neuronal α-synuclein is a prominent feature in Parkinson's disease. More recently, such abnormal protein aggregation has been reported to spread from cell to cell and exosomes are considered as important mediators. The focus of such research, however, has been primarily in neuro...

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Vydané v:	Brain (London, England : 1878) Ročník 143; číslo 5; s. 1476
Hlavní autori:	Guo, Min, Wang, Jian, Zhao, Yanxin, Feng, Yiwei, Han, Sida, Dong, Qiang, Cui, Mei, Tieu, Kim
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.05.2020
Predmet:	alpha-Synuclein - metabolism Animals Brain - metabolism Brain - pathology Exosomes - metabolism Humans Mice Mice, Inbred C57BL Microglia - metabolism Neurons - metabolism Parkinson Disease - metabolism Parkinson Disease - pathology transmission exosome microglia Parkinson’s disease α-synuclein
ISSN:	1460-2156, 1460-2156
On-line prístup:	Zistit podrobnosti o prístupe
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