cis-Diamminedichloroplatinum(II)-induced cell death through apoptosis in sensitive and resistant human ovarian carcinoma cell lines

We have studied the effects of the chemotherapeutic drug cis-diamminedichloroplatinum(II) (cis-platin) on three human ovarian carcinoma cell lines - one sensitive to the drug (CH1), one with acquired resistance (CH1cisR) and one with intrinsic resistance (SKOV-3). Previous work has shown that the 50...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology Jg. 37; H. 5; S. 463
Hauptverfasser:	Ormerod, M G, O'Neill, C, Robertson, D, Kelland, L R, Harrap, K R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Germany 1996
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Cell Adhesion - drug effects Cell Death Cisplatin - pharmacology DNA, Neoplasm - analysis DNA, Neoplasm - metabolism Drug Resistance, Neoplasm Electrophoresis, Agar Gel Female Flow Cytometry Humans Ovarian Neoplasms - pathology S Phase - drug effects Tumor Cells, Cultured
ISSN:	0344-5704
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