Electrochemical Dehydrogenative Cross‐Coupling of Quinoxalin‐2(1H)‐ones with Amines for the Synthesis of 3‐Aminoquinoxalinones

An efficient protocol for the synthesis of 3‐aminoquinoxalinones via the electrochemical dehydrogenative C‐3 amination of quinoxalin‐2(1H)‐ones was developed. With aliphatic amines and azoles as the nitrogen sources, a series of 3‐aminoquinoxalinones was obtained in up to 99% yield. This direct elec...

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Vydáno v:Advanced synthesis & catalysis Ročník 361; číslo 5; s. 1033 - 1041
Hlavní autoři: Li, Ke‐Jing, Xu, Kun, Liu, Yong‐Guo, Zeng, Cheng‐Chu, Sun, Bao‐Guo
Médium: Journal Article
Jazyk:angličtina
Vydáno: WEINHEIM Wiley 05.03.2019
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Témata:
Aliphatic amines
Amines
Chemistry
Chemistry, Applied
Chemistry, Organic
Dehydrogenation
dehydrogenative cross coupling
direct electrolysis
Heterocyclic compounds
oxidative amination
Oxidizing agents
Physical Sciences
quinoxalinone
Science & Technology
Synthesis
Transition metals
FUNCTIONALIZATION
DESIGN
POTENT
oxidative amination
BIOLOGICAL-ACTIVITY
RECEPTOR
quinoxalinone
dehydrogenative cross coupling
DERIVATIVES
direct electrolysis
QUINOXALINE
ISSN:1615-4150, 1615-4169
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Shrnutí:An efficient protocol for the synthesis of 3‐aminoquinoxalinones via the electrochemical dehydrogenative C‐3 amination of quinoxalin‐2(1H)‐ones was developed. With aliphatic amines and azoles as the nitrogen sources, a series of 3‐aminoquinoxalinones was obtained in up to 99% yield. This direct electrolytic method avoids the use of transition metals and external oxidants, and represents an appealing alternative for the synthesis of 3‐aminoquinoxalinones.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201800989