Time-dependent dual mode of action of COX-2 inhibition on mouse serum corticosterone levels

•Short-term COX-2 inhibition increased corticosterone levels,•Long-term COX-2 inhibition lowered corticosterone levels,•Corticosterone levels are regulated through a COX-2-dependent mechanism in mice. To elucidate the effect of cyclooxygenase-2 (COX-2) inhibition on corticosterone release, mice were...

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