Coding and decoding of oscillatory Ca2+ signals

About 30 years after their first observation, Ca2+ oscillations are now recognised as a universal mechanism of signal transduction. These oscillations are driven by periodic cycles of release and uptake of Ca2+ between the cytoplasm and the endoplasmic reticulum. Their frequency often increases with...

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Bibliographic Details
Published in:Seminars in cell & developmental biology Vol. 94; pp. 11 - 19
Main Authors: Wacquier, Benjamin, Voorsluijs, Valérie, Combettes, Laurent, Dupont, Geneviève
Format: Journal Article
Language:English
Published: Elsevier Ltd 01.10.2019
Subjects:
Calcium
Frequency decoding
IP3 receptors
Mitochondria
Stochasticity
Frequency decoding
IP3 receptors
Mitochondria
Stochasticity
Calcium
ISSN:1084-9521, 1096-3634, 1096-3634
Online Access:Get full text
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Summary:About 30 years after their first observation, Ca2+ oscillations are now recognised as a universal mechanism of signal transduction. These oscillations are driven by periodic cycles of release and uptake of Ca2+ between the cytoplasm and the endoplasmic reticulum. Their frequency often increases with the level of stimulation, which can be decoded by some molecules. However, it is becoming increasingly evident that the widespread core oscillatory mechanism is modulated in many ways, depending on the cell type and on the physiological conditions. Interplay with inositol 1,4,5-trisphosphate metabolism and with other Ca2+ stores as the extracellular medium or mitochondria can much affect the properties of these oscillations. In many cases, these finely tuned characteristics of Ca2+ oscillations impact the physiological response that is triggered by the signal. Moreover, oscillations are intrinsically irregular. This randomness can also be exploited by the cell. In this review, we discuss evidences of these additional manifestations of the versatility of Ca2+ signalling.
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ISSN:1084-9521
1096-3634
1096-3634
DOI:10.1016/j.semcdb.2019.01.008