Antimicrobial efficacy of a hemilabile Pt(II)-NHC compound against drug-resistant S. aureus and Enterococcus

Three platinum(II)-N-heterocyclic carbene (NHC) compounds [Pt(L )Cl](PF ) (1), [Pt(L )(COD)](PF ) (2) and [Pt(L )Cl ] (3) were synthesized bearing pyridyl-functionalized butenyl-tethered (L H) and -butyl tethered (L H) NHC ligands, and their antibacterial activity against clinically relevant human p...

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Veröffentlicht in:Dalton transactions : an international journal of inorganic chemistry Jg. 52; H. 7; S. 1876
Hauptverfasser: Kaur, Mandeep, Thakare, Ritesh, Bhattacherya, Arindom, Murugan, Prem Anand, Kaul, Grace, Shukla, Manjulika, Singh, Alok Kr, Matheshwaran, Saravanan, Chopra, Sidharth, Bera, Jitendra K
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 14.02.2023
Schlagworte:
Animals
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
Enterococcus
Humans
Methicillin-Resistant Staphylococcus aureus
Mice
Microbial Sensitivity Tests
Staphylococcus aureus
ISSN:1477-9234, 1477-9234
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Zusammenfassung:Three platinum(II)-N-heterocyclic carbene (NHC) compounds [Pt(L )Cl](PF ) (1), [Pt(L )(COD)](PF ) (2) and [Pt(L )Cl ] (3) were synthesized bearing pyridyl-functionalized butenyl-tethered (L H) and -butyl tethered (L H) NHC ligands, and their antibacterial activity against clinically relevant human pathogens was evaluated. Complex 1 was designed to have one of its metal coordination sites masked with a hemilabile butenyl group. The antibacterial activity spectrum against the ESKAPE panel of pathogens shows superior activity of 1 compared to 2 and 3 against the Gram-positive pathogen. Complex 1 showed equipotent activity against clinical drug-resistant and isolates. Furthermore, 1 demonstrated concentration-dependent bactericidal activity with a long post-antibiotic effect, eradicated preformed biofilm and synergized with gentamicin and minocycline for combinatorial antimicrobial therapy. Under conditions, 1 displayed potent activity in reducing bacterial load in a murine thigh infection model, similar to vancomycin, albeit at 2.5× less dosage. An array of experiments reveals key characteristics for the hemilabile complex 1 as a potential anti-staphylococcal drug.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-9234
1477-9234
DOI:10.1039/d2dt03365h