Expanding the Use of Ex Situ Organ Machine Perfusion Beyond Transplantation

ABSTRACT Machine perfusion preservation of grafts has become the gold standard organ preservation method. It has been developed to improve the quality of grafts due to the increasing gap between demand and supply of organs for transplantation. Following successful long‐term machine perfusion preserv...

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Vydáno v:Artificial organs Ročník 49; číslo 8; s. 1229 - 1235
Hlavní autoři: Martins, Paulo N., Edil, Barish H., McNally, Lacey, Battula, Narendra R.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Wiley Subscription Services, Inc 01.08.2025
Témata:
Animals
Bioengineering
Chemotherapy
ex situ perfusion
ex vivo perfusion
Gene therapy
Humans
isolated organ perfusion
machine perfusion
organ preservation
Organ Preservation - instrumentation
Organ Preservation - methods
Organ Transplantation - methods
Organs
Perfusion
Perfusion - instrumentation
Perfusion - methods
Preservation
research models
Transplantation
trials
Xenotransplantation
machine perfusion
ex situ perfusion
trials
isolated organ perfusion
research models
transplantation
ex vivo perfusion
organ preservation
ISSN:0160-564X, 1525-1594, 1525-1594
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Shrnutí:ABSTRACT Machine perfusion preservation of grafts has become the gold standard organ preservation method. It has been developed to improve the quality of grafts due to the increasing gap between demand and supply of organs for transplantation. Following successful long‐term machine perfusion preservation with automated commercial devices developed for preservation of organs for transplantation, there is increasing interest in utilizing perfused discarded human organs and xenografts for a variety of purposes beyond transplantation including gene therapy and modulation, drug testing, chemotherapy, ex vivo surgery, organ supporting systems, bioengineering, and surgical training and education. Here, we review all current and potential applications of machine perfusion preservation. Machine perfusion preservation of grafts has become the gold standard organ preservation method. There is increasing interest in utilizing perfused discarded human organs for a variety of purposes beyond transplantation, including gene therapy and modulation, drug testing, chemotherapy, ex vivo surgery, bioengineering, and surgical education/training. Here, we review all current and potential applications of machine perfusion preservation.
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ISSN:0160-564X
1525-1594
1525-1594
DOI:10.1111/aor.15011