Expanding the Use of Ex Situ Organ Machine Perfusion Beyond Transplantation

ABSTRACT Machine perfusion preservation of grafts has become the gold standard organ preservation method. It has been developed to improve the quality of grafts due to the increasing gap between demand and supply of organs for transplantation. Following successful long‐term machine perfusion preserv...

Full description

Saved in:
Bibliographic Details
Published in:Artificial organs Vol. 49; no. 8; pp. 1229 - 1235
Main Authors: Martins, Paulo N., Edil, Barish H., McNally, Lacey, Battula, Narendra R.
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.08.2025
Subjects:
Animals
Bioengineering
Chemotherapy
ex situ perfusion
ex vivo perfusion
Gene therapy
Humans
isolated organ perfusion
machine perfusion
organ preservation
Organ Preservation - instrumentation
Organ Preservation - methods
Organ Transplantation - methods
Organs
Perfusion
Perfusion - instrumentation
Perfusion - methods
Preservation
research models
Transplantation
trials
Xenotransplantation
machine perfusion
ex situ perfusion
trials
isolated organ perfusion
research models
transplantation
ex vivo perfusion
organ preservation
ISSN:0160-564X, 1525-1594, 1525-1594
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Machine perfusion preservation of grafts has become the gold standard organ preservation method. It has been developed to improve the quality of grafts due to the increasing gap between demand and supply of organs for transplantation. Following successful long‐term machine perfusion preservation with automated commercial devices developed for preservation of organs for transplantation, there is increasing interest in utilizing perfused discarded human organs and xenografts for a variety of purposes beyond transplantation including gene therapy and modulation, drug testing, chemotherapy, ex vivo surgery, organ supporting systems, bioengineering, and surgical training and education. Here, we review all current and potential applications of machine perfusion preservation. Machine perfusion preservation of grafts has become the gold standard organ preservation method. There is increasing interest in utilizing perfused discarded human organs for a variety of purposes beyond transplantation, including gene therapy and modulation, drug testing, chemotherapy, ex vivo surgery, bioengineering, and surgical education/training. Here, we review all current and potential applications of machine perfusion preservation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:0160-564X
1525-1594
1525-1594
DOI:10.1111/aor.15011