Redondoviridae, a Family of Small, Circular DNA Viruses of the Human Oro-Respiratory Tract Associated with Periodontitis and Critical Illness

The global virome is largely uncharacterized but is now being unveiled by metagenomic DNA sequencing. Exploring the human respiratory virome, in particular, can provide insights into oro-respiratory diseases. Here, we use metagenomics to identify a family of small circular DNA viruses-named Redondov...

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Veröffentlicht in:Cell host & microbe Jg. 25; H. 5; S. 719
Hauptverfasser: Abbas, Arwa A, Taylor, Louis J, Dothard, Marisol I, Leiby, Jacob S, Fitzgerald, Ayannah S, Khatib, Layla A, Collman, Ronald G, Bushman, Frederic D
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 08.05.2019
Schlagworte:
Adult
Aged
Aged, 80 and over
Critical Illness
DNA Virus Infections - virology
DNA Viruses - classification
DNA Viruses - genetics
DNA Viruses - isolation & purification
DNA Viruses - pathogenicity
DNA, Circular - genetics
DNA, Viral - genetics
Female
Humans
Male
Metagenomics
Middle Aged
Mouth - virology
Periodontitis - virology
Respiratory System - virology
Young Adult
redondoviridae
virome
vientovirus
brisavirus
critical illness
CRESS DNA
periodontitis
viral metagenomics
oro-respiratory virus
redondovirus
ISSN:1934-6069, 1934-6069
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Zusammenfassung:The global virome is largely uncharacterized but is now being unveiled by metagenomic DNA sequencing. Exploring the human respiratory virome, in particular, can provide insights into oro-respiratory diseases. Here, we use metagenomics to identify a family of small circular DNA viruses-named Redondoviridae-associated with human diseases. We first identified two redondovirus genomes from bronchoalveolar lavage samples from human lung donors. We then queried thousands of metagenomic samples and recovered 17 additional complete redondovirus genomes. Detections were exclusively in human samples and mostly from respiratory tract and oro-pharyngeal sites, where Redondoviridae was the second most prevalent eukaryotic DNA virus family. Redondovirus sequences were associated with periodontal disease, and abundances decreased with treatment. Some critically ill patients in a medical intensive care unit were found to harbor high levels of redondoviruses in respiratory samples. These results suggest that redondoviruses colonize human oro-respiratory sites and can bloom in several human disorders.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1934-6069
1934-6069
DOI:10.1016/j.chom.2019.04.001