Rationally designed peptide induces apoptosis and cell cycle modulation in resistant melanoma

The ineffectiveness of conventional therapies against melanoma necessitates the development of novel approaches characterized by high selectivity and low systemic toxicity. Using computational optimization, KW18, a synthetic α-helical peptide, was rationally engineered. It incorporates conserved bio...

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Veröffentlicht in:	Biochimica et biophysica acta. General subjects Jg. 1870; H. 1; S. 130877
Hauptverfasser:	Rocha, Layza Sá, Jacobowski, Ana Cristina, Thiburcio, Eduarda, Pereira, Rafael Araujo, Almeida, Claudiane Vilharroel, Gutierrez, Camila De Oliveira, de Andrade Farias Rodrigues, Thaís, Oliveira, Rodrigo Juliano, Taveira, Gabriel B., Hiane, Priscila Aiko, de Araújo Boleti, Ana Paula, Franco, Octávio Luiz, Cardoso, Marlon Henrique, Macedo, Maria Ligia Rodrigues
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.01.2026
Schlagworte:	Animals Anticancer peptide Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Cell Cycle - drug effects Cell Line, Tumor Computational design Drug Design Drug Resistance, Neoplasm - drug effects Humans Melanoma Melanoma - drug therapy Melanoma - pathology Mice Peptides - chemical synthesis Peptides - chemistry Peptides - pharmacology Tumor-selective peptide Tumor-selective peptide Melanoma Computational design Anticancer peptide Apoptosis
ISSN:	0304-4165, 1872-8006, 1872-8006
Online-Zugang:	Volltext
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