Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes

Pharmacologically induced glycosuria elicits adaptive responses in glucose homeostasis and hormone release. In type 2 diabetes (T2D), along with decrements in plasma glucose and insulin levels and increments in glucagon release, sodium-glucose cotransporter 2 (SGLT2) inhibitors induce stimulation of...

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Bibliographic Details
Published in:	Diabetes (New York, N.Y.) Vol. 65; no. 5; p. 1190
Main Authors:	Ferrannini, Ele, Baldi, Simona, Frascerra, Silvia, Astiarraga, Brenno, Heise, Tim, Bizzotto, Roberto, Mari, Andrea, Pieber, Thomas R, Muscelli, Elza
Format:	Journal Article
Language:	English
Published:	United States 01.05.2016
Subjects:	3-Hydroxybutyric Acid - agonists 3-Hydroxybutyric Acid - blood 3-Hydroxybutyric Acid - metabolism Algorithms Benzhydryl Compounds - administration & dosage Benzhydryl Compounds - adverse effects Benzhydryl Compounds - therapeutic use C-Reactive Protein - analysis Carbohydrate Metabolism - drug effects Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - urine Energy Metabolism - drug effects Glucagon - blood Glucagon - metabolism Glucagon-Like Peptide 1 - blood Glucose Intolerance - blood Glucose Intolerance - drug therapy Glucose Intolerance - metabolism Glucose Intolerance - urine Glucosides - administration & dosage Glucosides - adverse effects Glucosides - therapeutic use Glycosuria - chemically induced Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Insulin - blood Insulin - metabolism Insulin Secretion Lipid Metabolism - drug effects Lipolysis - drug effects Membrane Transport Modulators - administration & dosage Membrane Transport Modulators - adverse effects Membrane Transport Modulators - therapeutic use Renal Elimination - drug effects Sodium-Glucose Transporter 2 - metabolism Sodium-Glucose Transporter 2 Inhibitors Time Factors
ISSN:	1939-327X, 1939-327X
Online Access:	Get more information
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