What Is a Significant Nuclear Groove in Thyroid Fine Needle Aspiration Cytology?

ABSTRACT Background Nuclear grooves are an important diagnostic feature in thyroid fine needle aspiration (FNA). However, their exact role remains undefined. Materials and Methods This study includes both retrospective and prospective analyses of the significance of identifying and counting deep gro...

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Vydáno v:Diagnostic cytopathology Ročník 53; číslo 9; s. 437 - 446
Hlavní autoři: El Hag, Imad A., Al‐Subaie, Sadeem, Asiri, Shuaa M., Alotaibi, Fadel Z., Alabashi, Somya M., Alsheikh, Abdulmalik, Alghamdi, Abrar G.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Hoboken, USA John Wiley & Sons, Inc 01.09.2025
Wiley Subscription Services, Inc
Témata:
Biopsy
Biopsy, Fine-Needle - methods
Carcinoma, Papillary - pathology
Cell Nucleus - pathology
Cellular biology
Female
Humans
Male
Middle Aged
Prospective Studies
Retrospective Studies
Thyroid Cancer, Papillary - pathology
Thyroid gland
Thyroid Gland - pathology
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - pathology
ISSN:8755-1039, 1097-0339, 1097-0339
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Shrnutí:ABSTRACT Background Nuclear grooves are an important diagnostic feature in thyroid fine needle aspiration (FNA). However, their exact role remains undefined. Materials and Methods This study includes both retrospective and prospective analyses of the significance of identifying and counting deep grooves under low‐power magnification (20×) in Pap‐stained cytology smears for the classification of thyroid FNA results and, consequently, patient management. Result Two cut‐off points have been identified to stratify thyroid smears into three categories: benign with no grooves identified, 1–9 grooves in indeterminate cases, and ≥ 10 grooves in papillary thyroid carcinoma (PTC). Deep groove identification and counting under 20× magnification are highly reproducible between observers (K = 0.61). Using groove‐based criteria instead of the archival Bethesda System for Reporting Thyroid Cytology (BSRTC) leads to a significantly higher diagnosis of follicular adenomas as benign (p < 0.0001), with fewer noninvasive follicular thyroid neoplasms with papillary‐like nuclear features (NIFTP) categorized as benign (p = 0.002). The follicular variant of papillary carcinomas (FV‐PTC), previously considered indeterminate, showed a significant decline (p < 0.001), and false‐negative diagnoses of PTC and FV‐PTC were eliminated. A significant difference favoring the groove‐based approach was noted regarding specificity and positive (PLR) and negative (NLR) likelihood ratios (p = 0.0014). Finally, a substantial reduction in the false‐negative rate was observed prospectively (p = 0.0014). The number of unnecessary surgeries among benign cases has decreased. Conclusion Incorporating the presence and frequency of deep nuclear grooves seen at 20× magnification improves the outcome of thyroid FNA classification and overall patient management.
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ISSN:8755-1039
1097-0339
1097-0339
DOI:10.1002/dc.25491