Behavioural and demographic factors associated with occurrence of non-melanoma skin cancer in organ transplant recipients

Non-melanoma skin cancers (NMSC) are the most common epithelial malignancies in organ transplantation recipients (OTRs). In Italy, incidence rates of post- transplantation NMSC are approximately 5% after 5 years and 10% after 10 years since organ transplantation. The objective was to describe risk f...

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Published in:Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia Vol. 155; no. 5; p. 669
Main Authors: Fania, Luca, Abeni, Damiano, Esposito, Ilaria, Spagnoletti, Gionata, Citterio, Franco, Romagnoli, Jacopo, Castriota, Marina, Ricci, Francesco, Moro, Francesco, Perino, Francesca, Mazzanti, Cinzia, De Simone, Clara, Peris, Ketty
Format: Journal Article
Language:English
Published: Italy 01.10.2020
ISSN:1827-1820, 1827-1820
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Summary:Non-melanoma skin cancers (NMSC) are the most common epithelial malignancies in organ transplantation recipients (OTRs). In Italy, incidence rates of post- transplantation NMSC are approximately 5% after 5 years and 10% after 10 years since organ transplantation. The objective was to describe risk factors associated with NMSC in a cohort of renal and liver transplant recipients, in a single-center longitudinal study. Renal and liver transplant patients, who underwent transplantation between June 1985 and December 2015, were visited for the first time or followed-up in a dedicated outpatient clinic every six months until July 2016. We included 356 renal and 76 liver transplant patients. 108 OTRs (25.6%) presented 299 NMSC. 74 patients developed actinic keratosis (17.1%), 36 patients squamous cell carcinoma (8.5%), and 52 patients basal cell carcinoma (12.3%). Time from transplantation and kidney transplant were the main risk factors for NMSC. Higher incidences of all NMSC were observed in patients >60 years, males and smokers, while decreased incidences were detected in individuals with higher educational levels. Multiple logistic regression models confirmed that male gender (RR 3.3, P=0.001), cigarette smoking (RR 2.0, P=0.026), light eye color (RR 2.9, P=0.001), and family history of cancer (RR 1.8, P=0.042) were independently associated with NMSC. Dermatological follow-up is important in OTRs, due to the higher risk of tumors and mainly NMSC. Clinical and environmental factors, including cigarette smoking, are useful in characterizing OTR with higher risk of NMSC.
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ISSN:1827-1820
1827-1820
DOI:10.23736/S0392-0488.18.06099-6