Joint analysis of left‐censored longitudinal biomarker and binary outcome via latent class modeling

Joint latent class modeling is an appealing approach for evaluating the association between a longitudinal biomarker and clinical outcome when the study population is heterogeneous. The link between the biomarker trajectory and the risk of event is reflected by the latent classes, which accommodate...

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Bibliographic Details
Published in:Statistics in medicine Vol. 37; no. 13; pp. 2162 - 2173
Main Authors: Li, Menghan, Kong, Lan
Format: Journal Article
Language:English
Published: England Wiley Subscription Services, Inc 15.06.2018
Subjects:
Biomarkers
joint modeling
Latent class analysis
limit of detection (LOD)
longitudinal biomarker
Monte Carlo EM
limit of detection (LOD)
joint modeling
longitudinal biomarker
Monte Carlo EM
ISSN:0277-6715, 1097-0258, 1097-0258
Online Access:Get full text
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Summary:Joint latent class modeling is an appealing approach for evaluating the association between a longitudinal biomarker and clinical outcome when the study population is heterogeneous. The link between the biomarker trajectory and the risk of event is reflected by the latent classes, which accommodate the underlying population heterogeneity. The estimation of joint latent class models may be complicated by the censored data in the biomarker measurements due to detection limits. We propose a modified likelihood function under the parametric assumption of biomarker distribution and develop a Monte Carlo expectation‐maximization algorithm for joint analysis of a biomarker and a binary outcome. We conduct simulation studies to demonstrate the satisfactory performance of our Monte Carlo expectation‐maximization algorithm and the superiority of our method to the naive imputation method for handling censored biomarker data. In addition, we apply our method to the Genetic and Inflammatory Markers of Sepsis study to investigate the role of inflammatory biomarker profile in predicting 90‐day mortality for patients hospitalized with community‐acquired pneumonia.
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ISSN:0277-6715
1097-0258
1097-0258
DOI:10.1002/sim.7642