Immunoinformatics-guided vaccine design: A review with case study on Marburg virus

A primary concern for world health is the emergence of new infectious diseases. Conventional vaccine development techniques are time-consuming and often limited by issues such as antigen availability and safety concerns. Immunoinformatics, a computational approach that integrates immunology and info...

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Vydáno v:Biochemical and biophysical research communications Ročník 782; s. 152572
Hlavní autoři: Rao, Dharmendrasinh F., Patel, Saumya K., Pandya, Himanshu A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 30.09.2025
Témata:
Adjuvant
Animals
Computational Biology - methods
Drug Design
Humans
Immune simulation
Immunoinformatics
Marburg Virus Disease - immunology
Marburg Virus Disease - prevention & control
Marburg Virus Disease - virology
Marburgvirus - immunology
Molecular docking
Multi-epitope
Vaccine Development - methods
Viral Vaccines - chemistry
Viral Vaccines - immunology
Adjuvant
Immune simulation
Multi-epitope
Molecular docking
Immunoinformatics
ISSN:0006-291X, 1090-2104, 1090-2104
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Shrnutí:A primary concern for world health is the emergence of new infectious diseases. Conventional vaccine development techniques are time-consuming and often limited by issues such as antigen availability and safety concerns. Immunoinformatics, a computational approach that integrates immunology and informatics, presents a promising solution for accelerating vaccine design. Researchers can rapidly identify potential vaccine candidates by leveraging computational tools and databases, predict their immunogenicity and safety profiles, and optimize their design. This review explores immunoinformatics approaches for vaccine design and illustrates them through a case study on the Marburg virus. We highlight the tools and databases involved to expedite the vaccine development process and improve global health outcomes. The designed vaccine exhibited desirable physicochemical and biological interaction results. This review on the use of the immunoinformatics approach to enhance vaccine development against emerging infectious diseases provides an efficient first step in the vaccine development process. •In silico pipeline presented for designing multi-epitope vaccines.•The Marburg virus vaccine candidate showed high antigenicity and an immune response.•Review compiles key tools and methods in immunoinformatics-based vaccine design.
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ISSN:0006-291X
1090-2104
1090-2104
DOI:10.1016/j.bbrc.2025.152572