Genome-wide siRNA Screen Identifies the Radiosensitizing Effect of Downregulation of MASTL and FOXM1 in NSCLC

Lung cancer is the most common cancer worldwide and on top of that has a very poor prognosis, which is reflected by a 5-year survival rate of 5% to 15%. Radiotherapy is an integral part of most treatment regimens for this type of tumor, often combined with radiosensitizing cytotoxic drugs. In this s...

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Veröffentlicht in:	Molecular cancer therapeutics Jg. 14; H. 6; S. 1434
Hauptverfasser:	Nagel, Remco, Stigter-van Walsum, Marijke, Buijze, Marijke, van den Berg, Jaap, van der Meulen, Ida H, Hodzic, Jasmina, Piersma, Sander R, Pham, Thang V, Jiménez, Connie R, van Beusechem, Victor W, Brakenhoff, Ruud H
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.06.2015
Schlagworte:	Animals Blotting, Western Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - radiotherapy Cell Cycle - genetics Cell Cycle - radiation effects Cell Line, Tumor Down-Regulation - genetics Down-Regulation - radiation effects Forkhead Box Protein M1 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gamma Rays Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - radiation effects Genome, Human - genetics HEK293 Cells Humans Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Mice, Nude Microscopy, Confocal Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Phosphorylation - genetics Phosphorylation - radiation effects Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Small Interfering - genetics Survival Analysis Xenograft Model Antitumor Assays
ISSN:	1538-8514, 1538-8514
Online-Zugang:	Weitere Angaben
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