The complexity of recognition of ubiquitinated substrates by the 26S proteasome

The Ubiquitin Proteasome System (UPS) was discovered in two steps. Initially, APF-1 (ATP-dependent proteolytic Factor 1) later identified as ubiquitin (Ub), a hitherto known protein of unknown function, was found to covalently modify proteins. This modification led to degradation of the tagged prote...

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Bibliographic Details

Published in:	Biochimica et biophysica acta Vol. 1843; no. 1; pp. 86 - 96
Main Authors:	Ciechanover, Aaron, Stanhill, Ariel
Format:	Journal Article
Language:	English
Published:	Netherlands 01.01.2014
Subjects:	Animals Binding Sites Humans Models, Molecular Polyubiquitin - chemistry Polyubiquitin - metabolism Proteasome Endopeptidase Complex - metabolism Protein Binding Protein Sorting Signals - physiology Proteolysis Substrate Specificity Ubiquitinated Proteins - chemistry Ubiquitinated Proteins - metabolism Ubiquitin 26S proteasome
ISSN:	0167-4889, 0006-3002
Online Access:	Get full text
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