Abnormal gut microbiota and bile acids in patients with first‐episode major depressive disorder and correlation analysis

Aim Gut microbiota and its metabolite bile acids may play a significant role in the occurrence and development of major depressive disorder (MDD). Therefore, this study analyzes gut microbiota and bile acids, as well as their correlation in patients. Methods Thirty‐one patients with MDD and 29 healt...

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Published in:Psychiatry and clinical neurosciences Vol. 76; no. 7; pp. 321 - 328
Main Authors: Sun, Ning, Zhang, Jie, Wang, Jizhi, Liu, Zhifen, Wang, Xin, Kang, Pengli, Yang, Chunxia, Liu, Penghong, Zhang, Kerang
Format: Journal Article
Language:English
Published: Melbourne John Wiley & Sons Australia, Ltd 01.07.2022
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Subjects:
Acids
Bile
Bile acids
Correlation analysis
Discriminant analysis
Gut microbiota
Intestinal microflora
Liquid chromatography
major depressive disorder
Mass spectroscopy
Mental depression
Metabolism
Metabolites
Microbiota
Multidimensional scaling
Taurodeoxycholic acid
α‐Diversity
β‐Diversity
α-Diversity
major depressive disorder
bile acids
β-Diversity
gut microbiota
ISSN:1323-1316, 1440-1819, 1440-1819
Online Access:Get full text
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Summary:Aim Gut microbiota and its metabolite bile acids may play a significant role in the occurrence and development of major depressive disorder (MDD). Therefore, this study analyzes gut microbiota and bile acids, as well as their correlation in patients. Methods Thirty‐one patients with MDD and 29 healthy controls (HCs) were enrolled in this study. We collected their both blood and feces. Plasma bile acid content was determined by liquid chromatography‐mass spectrometry and gut microbiota was detected by 16SrRNA gene sequencing and subsequently analyzed. We also analyzed the correlation between different gut microbiota, bile acids, and Hamilton Depression (HAMD) score. Results The α‐diversity analysis found that Simpson and Pielou evenness index was much higher in HCs than in the patients with MDD. The β‐diversity of the two groups were differences by nonmetric multidimensional scaling analysis. Linear discriminant analysis effect size analysis identified 16 different strains. Bile acids detection showed that 23‐nordeoxycholic acid in patients with MDD was significantly higher than in HCs, whereas taurolithocholic acid (TLCA), glycolithocholic acid (GLCA), and lithocholic acid 3‐sulfate were significantly lower. Spearman correlation analysis showed that Turicibacteraceae, Turicibacterales, and Turicibacter were positively related with TLCA, GLCA, glycodeoxycholic acid (GDCA), and taurodeoxycholic acid, and were negatively correlated with HAMD score. At the same time, TLCA, GLCA, and GDCA were negatively correlated with HAMD score. Conclusions Gut microbiota and bile acids metabolism are disturbances in MDD, and there exists a correlation between gut microbiota and bile acids metabolism. Moreover, their interaction may be related to the pathophysiological mechanism of MDD.
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ISSN:1323-1316
1440-1819
1440-1819
DOI:10.1111/pcn.13368