Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial

High-risk persons were screened for lung cancer in a population-based, randomized, controlled trial that involved volume-based nodule management for further testing. At 10 years of follow-up, lung-cancer mortality was significantly lower in the screening group than in the control group (2.5 vs. 3.3...

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Veröffentlicht in:The New England journal of medicine Jg. 382; H. 6; S. 503 - 513
Hauptverfasser: de Koning, Harry J, van der Aalst, Carlijn M, de Jong, Pim A, Scholten, Ernst T, Nackaerts, Kristiaan, Heuvelmans, Marjolein A, Lammers, Jan-Willem J, Weenink, Carla, Yousaf-Khan, Uraujh, Horeweg, Nanda, van ’t Westeinde, Susan, Prokop, Mathias, Mali, Willem P, Mohamed Hoesein, Firdaus A.A, van Ooijen, Peter M.A, Aerts, Joachim G.J.V, den Bakker, Michael A, Thunnissen, Erik, Verschakelen, Johny, Vliegenthart, Rozemarijn, Walter, Joan E, ten Haaf, Kevin, Groen, Harry J.M, Oudkerk, Matthijs
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Massachusetts Medical Society 06.02.2020
Schlagworte:
Aged
Belgium - epidemiology
Computed tomography
Cone-Beam Computed Tomography
Consent
Death
Early Detection of Cancer - methods
False Positive Reactions
Female
Humans
Incidence
Lung cancer
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - epidemiology
Lung Neoplasms - mortality
Male
Medical diagnosis
Medical Overuse
Medical screening
Middle Aged
Mortality
Netherlands - epidemiology
Nodules
Population
Registries
Sex Factors
Smoking
Smoking - epidemiology
Software
Womens health
Belgium
Netherlands
United States > US
ISSN:0028-4793, 1533-4406, 1533-4406
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:High-risk persons were screened for lung cancer in a population-based, randomized, controlled trial that involved volume-based nodule management for further testing. At 10 years of follow-up, lung-cancer mortality was significantly lower in the screening group than in the control group (2.5 vs. 3.3 per 1000 person-years among male participants).
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Feature-3
ObjectType-Evidence Based Healthcare-1
ObjectType-Article-1
ObjectType-Feature-2
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1911793