Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1

Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54 . We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 indiv...

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Veröffentlicht in:Nature genetics Jg. 42; H. 9; S. 759 - 763
Hauptverfasser: Wang, Li-Dong, Zhou, Fu-You, Song, Xin, Jin, Yan, Li, Jiang-Man, Kong, Guo-Qiang, Cui, Juan, Zhang, Lian-Qun, Yang, Jie-Zhi, Li, Ji-Lin, Liu, Zhi-Cai, Gao, Wen-Jun, Yuan, Ling, Wei, Wu, Zhang, Yan-Rui, Wang, Wei-Peng, Sheyhidin, Ilyar, Li, Feng, Ren, Shu-Wei, Liu, Bin, Li, Dan, Ku, Jian-Wei, Fan, Zong-Min, Zhou, Sheng-Li, Zhao, Xue-Ke, Liu, Na, Ai, Yong-Hong, Shen, Fang-Fang, Cui, Wen-Yan, Huang, Jing, Yuan, Chao, Wu, Yue, Yue, Wen-Bin, Feng, Chang-Wei, Li, Hong-Lei, Wang, Yan, Lu, Yue, Yuan, Yi, Zhu, Wen-Liang, Liu, Min, Fu, Wen-Jing, Yang, Xia, Wang, Han-Jing, Han, Suo-Li, Chen, Jie, Han, Min, Wang, Hai-Yan, Zhang, Peng, Dong, Jin-Cheng, Xing, Guo-Lan, Guo, Ming, Chang, Zhi-Wei, Liu, Hai-Lin, Yuan, Zhi-Qing, Liu, Hai, Lu, Qin, Zhu, Fu-Guo, Yang, Xiu-Feng, Feng, Xiao-Shan, Wang, Zhou, Li, Yin, Qige, Qirenwang, Bai, Long-Tang, Yang, Wen-Jun, Chen, Long-Qi, Li, En-Min, Wu, Zhi-Yong, Cao, Wei-Ke, Wang, Jian-Po, Chen, Ji-Li, Ding, Guang-Cheng, Zhuang, Xiang, Zhou, Ying-Fa, Dong, Zi-Ming, Fan, Dong-Mei, He, Xin, Wang, Jin, Zhang, Qin-Xian, Jiao, Xin-Ying, Ji, Ai-Fang, Lu, Xiao-Mei, Wang, Jin-Sheng, Chang, Fu-Bao, Lu, Chang-Dong, Chen, Zhi-Guo, Fan, Zeng-Lin, Lin, Ruo-Bai, Liu, Tai-Jiang, Wei, Jin-Chang, Kong, Qing-Peng, Lan, Yu, Fan, Yu-Jing, Gao, Fu-Sheng, Wang, Tian-Yun, Xie, Dong, Chen, Shu-Qing, Yang, Wan-Cai, Hong, Jun-Yan, Qiu, Song-Liang, Cai, Zhi-Ming
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Nature Publishing Group US 01.09.2010
Nature Publishing Group
Schlagworte:
631/208/457
631/208/727/2000
692/699/67/1504/1477
Adenocarcinoma
Agriculture
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Cancer genetics
Cancer Research
Carcinoma
Cell differentiation
Disease susceptibility
Esophageal cancer
Gene Function
Genetic research
Genomes
Genomics
Human Genetics
letter
Squamous cell carcinoma
Uighurs
ISSN:1061-4036, 1546-1718
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54 . We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified a previously unknown susceptibility locus for ESCC: PLCE1 at 10q23 ( P Han combined for ESCC = 7.46 × 10 −56 , odds ratio (OR) = 1.43; P Uygur-Kazakh for ESCC = 5.70 × 10 −4 , OR = 1.53). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma and the same 11,013 control subjects ( PLCE1 , P Han for GCA = 1.74 × 10 −39 , OR = 1.55. PLCE1 has important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis.
ISSN:1061-4036
1546-1718
DOI:10.1038/ng.648