Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1
Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54 . We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 indiv...
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| Vydáno v: | Nature genetics Ročník 42; číslo 9; s. 759 - 763 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
New York
Nature Publishing Group US
01.09.2010
Nature Publishing Group |
| Témata: | |
| ISSN: | 1061-4036, 1546-1718 |
| On-line přístup: | Získat plný text |
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| Abstract | Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at
PLCE1
and
C20orf54
.
We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified a previously unknown susceptibility locus for ESCC:
PLCE1
at 10q23 (
P
Han combined for ESCC
= 7.46 × 10
−56
, odds ratio (OR) = 1.43;
P
Uygur-Kazakh for ESCC
= 5.70 × 10
−4
, OR = 1.53). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma and the same 11,013 control subjects (
PLCE1
,
P
Han for GCA
= 1.74 × 10
−39
, OR = 1.55.
PLCE1
has important biological implications for both ESCC and GCA.
PLCE1
might regulate cell growth, differentiation, apoptosis and angiogenesis. |
|---|---|
| AbstractList | Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at
PLCE1
and
C20orf54
.
We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified a previously unknown susceptibility locus for ESCC:
PLCE1
at 10q23 (
P
Han combined for ESCC
= 7.46 × 10
−56
, odds ratio (OR) = 1.43;
P
Uygur-Kazakh for ESCC
= 5.70 × 10
−4
, OR = 1.53). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma and the same 11,013 control subjects (
PLCE1
,
P
Han for GCA
= 1.74 × 10
−39
, OR = 1.55.
PLCE1
has important biological implications for both ESCC and GCA.
PLCE1
might regulate cell growth, differentiation, apoptosis and angiogenesis. Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54. |
| Audience | Academic |
| Author | Guo, Li Fan, Dong-Mei Li, Dan Li, En-Min Liu, Zhi-Cai Wang, Wei-Peng Zhu, Wen-Liang Song, Shuang Fan, Zeng-Lin Wang, Hai-Yan Wang, Ran Bai, Long-Tang Feng, Chang-Wei Liu, Hai-Lin Yang, Liu-Qin Liu, Bin Chang, Fu-Bao Chen, Bao-Ping Zhang, Zheng Yang, Wan-Cai Zhang, Xue-Jun Wu, Yue He, Xin Zhang, Qin-Xian Bao, Zhi-Qin Cui, Juan Zuo, Xian-Bo Xie, Dong Gao, Wen-Jun Han, Min Xu, Li-Yan Lian, Shi-Yong Wang, Tian-Yun Yuan, Ling Hong, Jun-Yan Lu, Xiao-Mei Shen, Zhong-Ying Zhang, Peng Wang, Zhou Ren, Shu-Wei Zhou, Ying-Fa Lu, Qin Feng, Xiao-Shan Yang, Jie-Zhi Dong, Zi-Ming Fan, Zong-Min Chang, Zhi-Wei Li, Xing-Chuan Lei, Guang-Yan Lin, Ruo-Bai Wei, Wu Chen, Zhi-Guo Guo, Zhi-Gang Qi, Hong Zhu, Fu-Guo Li, Feng Sheyhidin, Ilyar Han, Suo-Li Li, Ji-Lin Liu, Hai Yang, Xia Jin, Yan Wang, Jin Cao, Wei-Ke Kong, Guo-Qiang Zhang, Lian-Qun Yuan, Zhi-Qing Chen, Shu-Qing Li, Xue-Min Gao, She-Gan Gao, Fu-Sheng Zheng, Hou-Feng Wu, Zhi-Yong Miao, Jian-Jun Song, Xin Shen, Fang-Fang Zhuang, Xiang Wang, Jin-Sheng Kong, Qing-Peng Cai, Zhi-Ming Jiao, Xin-Ying Yuan, Chao Liu, Tai-Jiang Fu, Wen-Jing |
| Author_xml | – sequence: 1 givenname: Li-Dong surname: Wang fullname: Wang, Li-Dong email: ldwang@xxmu.edu.cn organization: Cancer Research Center, Xinxiang Medical University, Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 2 givenname: Fu-You surname: Zhou fullname: Zhou, Fu-You organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University, Department of Thoracic Surgery and Tumor Prevention Treatment, Anyang Tumor Hospital – sequence: 5 givenname: Xin surname: Song fullname: Song, Xin organization: Cancer Research Center, Xinxiang Medical University, Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 6 givenname: Yan surname: Jin fullname: Jin, Yan organization: Cancer Research Center, Xinxiang Medical University – sequence: 7 givenname: Jiang-Man surname: Li fullname: Li, Jiang-Man organization: Cancer Research Center, Xinxiang Medical University, Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 8 givenname: Guo-Qiang surname: Kong fullname: Kong, Guo-Qiang organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 10 givenname: Juan surname: Cui fullname: Cui, Juan organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 11 givenname: Lian-Qun surname: Zhang fullname: Zhang, Lian-Qun organization: Cancer Research Center, Xinxiang Medical University – sequence: 12 givenname: Jie-Zhi surname: Yang fullname: Yang, Jie-Zhi organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 13 givenname: Ji-Lin surname: Li fullname: Li, Ji-Lin organization: Cancer Research Center, Xinxiang Medical University, Department of Pathology and Thoracic Surgery, Linzhou Esophageal Cancer Hospital – sequence: 16 givenname: Zhi-Cai surname: Liu fullname: Liu, Zhi-Cai organization: Department of Thoracic Surgery, Tumor Hospital of Linzhou – sequence: 17 givenname: Wen-Jun surname: Gao fullname: Gao, Wen-Jun organization: Department of Thoracic Surgery, People's Hospital and Chinese Medicine Hospital of Linzhou – sequence: 18 givenname: Ling surname: Yuan fullname: Yuan, Ling organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University, Department of Thoracic Surgery and Radiotherapy, Cancer Hospital of Henan Province – sequence: 19 givenname: Wu surname: Wei fullname: Wei, Wu organization: Institute of Hematologic Disease and Department of Pathology, Changzhi Medical University – sequence: 20 givenname: Yan-Rui surname: Zhang fullname: Zhang, Yan-Rui organization: Department of Gastroenterology, Henan Provincial People's Hospital – sequence: 21 givenname: Wei-Peng surname: Wang fullname: Wang, Wei-Peng organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University, Department of Pathology and Thoracic Surgery, Centre for Health Screening and Endoscopy, Cixian Hospital – sequence: 22 givenname: Ilyar surname: Sheyhidin fullname: Sheyhidin, Ilyar organization: Department of Thoracic Surgery and Medical Research Center, The First Affiliated Hospital, Xinjiang Medical University – sequence: 23 givenname: Feng surname: Li fullname: Li, Feng organization: Department of Pathology, Shihezi University School of Medicine – sequence: 25 givenname: Shu-Wei surname: Ren fullname: Ren, Shu-Wei organization: Department of Oncology, Xinyang Central Hospital – sequence: 26 givenname: Bin surname: Liu fullname: Liu, Bin organization: Department of Gastroenterology, Beijing Tongren Hospital Affiliated to Capital Medical University – sequence: 27 givenname: Dan surname: Li fullname: Li, Dan organization: Cancer Research Center, Xinxiang Medical University, Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 28 givenname: Jian-Wei surname: Ku fullname: Ku, Jian-Wei organization: Department of Oncology, The First Affiliated Hospital of Nanyang Medical College – sequence: 29 givenname: Zong-Min surname: Fan fullname: Fan, Zong-Min organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 30 givenname: Sheng-Li surname: Zhou fullname: Zhou, Sheng-Li organization: Cancer Research Center, Xinxiang Medical University – sequence: 32 givenname: Xue-Ke surname: Zhao fullname: Zhao, Xue-Ke organization: Cancer Research Center, Xinxiang Medical University – sequence: 33 givenname: Na surname: Liu fullname: Liu, Na organization: Cancer Research Center, Xinxiang Medical University – sequence: 34 givenname: Yong-Hong surname: Ai fullname: Ai, Yong-Hong organization: Cancer Research Center, Xinxiang Medical University – sequence: 35 givenname: Fang-Fang surname: Shen fullname: Shen, Fang-Fang organization: Cancer Research Center, Xinxiang Medical University – sequence: 36 givenname: Wen-Yan surname: Cui fullname: Cui, Wen-Yan organization: Cancer Research Center, Xinxiang Medical University – sequence: 39 givenname: Jing surname: Huang fullname: Huang, Jing organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 40 givenname: Chao surname: Yuan fullname: Yuan, Chao organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 42 givenname: Yue surname: Wu fullname: Wu, Yue organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 43 givenname: Wen-Bin surname: Yue fullname: Yue, Wen-Bin organization: Department of Oncology, People's Hospital of Puyang – sequence: 44 givenname: Chang-Wei surname: Feng fullname: Feng, Chang-Wei organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 45 givenname: Hong-Lei surname: Li fullname: Li, Hong-Lei organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 46 givenname: Yan surname: Wang fullname: Wang, Yan organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 48 givenname: Yue surname: Lu fullname: Lu, Yue organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 49 givenname: Yi surname: Yuan fullname: Yuan, Yi organization: Cancer Research Center, Xinxiang Medical University – sequence: 50 givenname: Wen-Liang surname: Zhu fullname: Zhu, Wen-Liang organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 51 givenname: Min surname: Liu fullname: Liu, Min organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 52 givenname: Wen-Jing surname: Fu fullname: Fu, Wen-Jing organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 53 givenname: Xia surname: Yang fullname: Yang, Xia organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 54 givenname: Han-Jing surname: Wang fullname: Wang, Han-Jing organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 55 givenname: Suo-Li surname: Han fullname: Han, Suo-Li organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 56 givenname: Jie surname: Chen fullname: Chen, Jie organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 57 givenname: Min surname: Han fullname: Han, Min organization: Department of Gastroenterology and Thoracic Surgery, The First People's Hospital of Shangqiu – sequence: 58 givenname: Hai-Yan surname: Wang fullname: Wang, Hai-Yan organization: Cancer Research Center, Xinxiang Medical University – sequence: 59 givenname: Peng surname: Zhang fullname: Zhang, Peng organization: Cancer Research Center, Xinxiang Medical University – sequence: 61 givenname: Jin-Cheng surname: Dong fullname: Dong, Jin-Cheng organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 62 givenname: Guo-Lan surname: Xing fullname: Xing, Guo-Lan organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 64 givenname: Ming surname: Guo fullname: Guo, Ming organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 65 givenname: Zhi-Wei surname: Chang fullname: Chang, Zhi-Wei organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 66 givenname: Hai-Lin surname: Liu fullname: Liu, Hai-Lin organization: Cancer Research Center, Xinxiang Medical University – sequence: 68 givenname: Zhi-Qing surname: Yuan fullname: Yuan, Zhi-Qing organization: Cancer Research Center, Xinxiang Medical University – sequence: 69 givenname: Hai surname: Liu fullname: Liu, Hai organization: Department of Gastroenterology, The Third People's Hospital of Yunnan Province – sequence: 70 givenname: Qin surname: Lu fullname: Lu, Qin organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 72 givenname: Fu-Guo surname: Zhu fullname: Zhu, Fu-Guo organization: Department of Gastroenterology and Thoracic Surgery, The First People's Hospital of Shangqiu – sequence: 73 givenname: Xiu-Feng surname: Yang fullname: Yang, Xiu-Feng organization: Department of Surgery, Hebi Dahejian Hospital – sequence: 74 givenname: Xiao-Shan surname: Feng fullname: Feng, Xiao-Shan organization: Department of Oncology, The First Affiliated Hospital, Henan University of Science and Technology – sequence: 75 givenname: Zhou surname: Wang fullname: Wang, Zhou organization: Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University – sequence: 76 givenname: Yin surname: Li fullname: Li, Yin organization: Department of Thoracic Surgery and Radiotherapy, Cancer Hospital of Henan Province – sequence: 78 givenname: Qirenwang surname: Qige fullname: Qige, Qirenwang organization: Department of Internal Mongolia Medicine, The Affiliated Hospital, Inner Mongolia Medical College – sequence: 79 givenname: Long-Tang surname: Bai fullname: Bai, Long-Tang organization: Department of Internal Mongolia Medicine, The Affiliated Hospital, Inner Mongolia Medical College – sequence: 80 givenname: Wen-Jun surname: Yang fullname: Yang, Wen-Jun organization: Department of Biotechnology, Ningxia Medical University – sequence: 83 givenname: Long-Qi surname: Chen fullname: Chen, Long-Qi organization: Department of Thoracic and Cardiovascular Surgery, West China Hospital, Sichuan University – sequence: 84 givenname: En-Min surname: Li fullname: Li, En-Min organization: Department of Oncologic Pathology, and Department of Biochemistry and Molecular Biology, Medical College of Shantou University – sequence: 86 givenname: Zhi-Yong surname: Wu fullname: Wu, Zhi-Yong organization: Department of Oncologic Pathology, and Department of Biochemistry and Molecular Biology, Medical College of Shantou University – sequence: 87 givenname: Wei-Ke surname: Cao fullname: Cao, Wei-Ke organization: Central Laboratory, Huaian No.1 Hospital, Nanjing Medical University – sequence: 88 givenname: Jian-Po surname: Wang fullname: Wang, Jian-Po organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University, Department of Thoracic Surgery and Tumor Prevention Treatment, Anyang Tumor Hospital – sequence: 90 givenname: Ji-Li surname: Chen fullname: Chen, Ji-Li organization: Department of Pathology and Thoracic Surgery, Centre for Health Screening and Endoscopy, Cixian Hospital – sequence: 91 givenname: Guang-Cheng surname: Ding fullname: Ding, Guang-Cheng organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 92 givenname: Xiang surname: Zhuang fullname: Zhuang, Xiang organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 93 givenname: Ying-Fa surname: Zhou fullname: Zhou, Ying-Fa organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 97 givenname: Zi-Ming surname: Dong fullname: Dong, Zi-Ming organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 98 givenname: Dong-Mei surname: Fan fullname: Fan, Dong-Mei organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 99 givenname: Xin surname: He fullname: He, Xin organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 100 givenname: Jin surname: Wang fullname: Wang, Jin organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 102 givenname: Qin-Xian surname: Zhang fullname: Zhang, Qin-Xian organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 103 givenname: Xin-Ying surname: Jiao fullname: Jiao, Xin-Ying organization: Department of Pathology and Thoracic Surgery, Linzhou Esophageal Cancer Hospital – sequence: 105 givenname: Ai-Fang surname: Ji fullname: Ji, Ai-Fang organization: Institute of Hematologic Disease and Department of Pathology, Changzhi Medical University – sequence: 106 givenname: Xiao-Mei surname: Lu fullname: Lu, Xiao-Mei organization: Department of Thoracic Surgery and Medical Research Center, The First Affiliated Hospital, Xinjiang Medical University – sequence: 107 givenname: Jin-Sheng surname: Wang fullname: Wang, Jin-Sheng organization: Institute of Hematologic Disease and Department of Pathology, Changzhi Medical University – sequence: 108 givenname: Fu-Bao surname: Chang fullname: Chang, Fu-Bao organization: Department of Thoracic Surgery, People's Hospital and Chinese Medicine Hospital of Linzhou – sequence: 109 givenname: Chang-Dong surname: Lu fullname: Lu, Chang-Dong organization: Department of Thoracic Surgery and Tumor Prevention Treatment, Anyang Tumor Hospital – sequence: 110 givenname: Zhi-Guo surname: Chen fullname: Chen, Zhi-Guo organization: Cancer Research Center, Xinxiang Medical University – sequence: 112 givenname: Zeng-Lin surname: Fan fullname: Fan, Zeng-Lin organization: Department of Pathology and Thoracic Surgery, Centre for Health Screening and Endoscopy, Cixian Hospital – sequence: 113 givenname: Ruo-Bai surname: Lin fullname: Lin, Ruo-Bai organization: Department of Thoracic Surgery, Fujian Medical University Union Hospital – sequence: 114 givenname: Tai-Jiang surname: Liu fullname: Liu, Tai-Jiang organization: Department of Surgery, The Red Cross Hospital of Huojia – sequence: 115 givenname: Jin-Chang surname: Wei fullname: Wei, Jin-Chang organization: Department of Pathology and Thoracic Surgery, Linzhou Esophageal Cancer Hospital – sequence: 116 givenname: Qing-Peng surname: Kong fullname: Kong, Qing-Peng organization: State Key Laboratory of Genetic Resource and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences – sequence: 117 givenname: Yu surname: Lan fullname: Lan, Yu organization: Department of Gastroenterology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University – sequence: 118 givenname: Yu-Jing surname: Fan fullname: Fan, Yu-Jing organization: Department of Gastroenterology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University – sequence: 119 givenname: Fu-Sheng surname: Gao fullname: Gao, Fu-Sheng organization: Department of Gastroenterology, Beijing Tongren Hospital Affiliated to Capital Medical University – sequence: 120 givenname: Tian-Yun surname: Wang fullname: Wang, Tian-Yun organization: Cancer Research Center, Xinxiang Medical University – sequence: 121 givenname: Dong surname: Xie fullname: Xie, Dong organization: Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences – sequence: 122 givenname: Shu-Qing surname: Chen fullname: Chen, Shu-Qing organization: College of Pharmaceutical Sciences, Zhejiang University – sequence: 123 givenname: Wan-Cai surname: Yang fullname: Yang, Wan-Cai organization: Cancer Research Center, Xinxiang Medical University, Present addresses: Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA (W.-C.Y.); Department of Environment and Occupational Health, School of Public Health, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA (J.-Y.H.) – sequence: 124 givenname: Jun-Yan surname: Hong fullname: Hong, Jun-Yan organization: College of Pharmaceutical Sciences, Zhejiang University, Present addresses: Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA (W.-C.Y.); Department of Environment and Occupational Health, School of Public Health, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA (J.-Y.H.) – sequence: 126 givenname: Song-Liang surname: Qiu fullname: Qiu, Song-Liang organization: Department of Basic Oncology and Pathology at College of Medicine, Henan Key Laboratory for Esophageal Cancer Research, The First and The Second Affiliated Hospital, Zhengzhou University – sequence: 127 givenname: Zhi-Ming surname: Cai fullname: Cai, Zhi-Ming organization: Guangdong Key Laboratory of Male Reprodutive Medicine and Genetics, Peking University Shenzhen Hospital |
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| References | Bunney (CR25) 2006; 21 Zhang (CR12) 2010; 5 Yang (CR7) 2005; 6 Wang, Hong, Qiu, Gao, Yang (CR29) 1993; 53 Messmann (CR10) 2001; 15 Zhang (CR13) 2000; 67 Bai (CR27) 2004; 64 Hu (CR15) 2005; 65 Tran (CR16) 2005; 113 Bourguignon, Gilad, Brightman, Diedrich, Singleton (CR26) 2006; 281 Price (CR19) 2006; 38 Cui (CR14) 2009; 137 Zhang (CR20) 2009; 361 Li, Edamatsu, Kitazawa, Kitazawa, Kataoka (CR28) 2009; 30 Parkin, Bray, Ferlay, Pisani (CR1) 2005; 55 Hongo, Nagasaki, Shoji (CR3) 2009; 24 CR5 Siassi, Ghadirian (CR6) 2005; 29 Cheung, Liu (CR4) 2009; 38 Kamangar, Chow, Abnet, Dawsey (CR17) 2009; 38 Sun (CR8) 2007; 24 Brown (CR11) 2001; 153 Chow (CR18) 1998; 90 Chen (CR21) 2009; 85 Rhee (CR23) 2001; 70 Ke (CR2) 2002; 102 Bunney, Baxendale, Katan (CR24) 2009; 49 Morita (CR9) 2010; 15 Xu (CR22) 2009; 85 DM Parkin (BFng648_CR1) 2005; 55 Y Bai (BFng648_CR27) 2004; 64 M Li (BFng648_CR28) 2009; 30 WH Chow (BFng648_CR18) 1998; 90 L Ke (BFng648_CR2) 2002; 102 M Hongo (BFng648_CR3) 2009; 24 LD Wang (BFng648_CR29) 1993; 53 G Sun (BFng648_CR8) 2007; 24 AL Price (BFng648_CR19) 2006; 38 F Kamangar (BFng648_CR17) 2009; 38 BFng648_CR5 F Siassi (BFng648_CR6) 2005; 29 N Hu (BFng648_CR15) 2005; 65 S Xu (BFng648_CR22) 2009; 85 R Cui (BFng648_CR14) 2009; 137 J Chen (BFng648_CR21) 2009; 85 CX Yang (BFng648_CR7) 2005; 6 H Messmann (BFng648_CR10) 2001; 15 GD Tran (BFng648_CR16) 2005; 113 LY Bourguignon (BFng648_CR26) 2006; 281 WY Cheung (BFng648_CR4) 2009; 38 LM Brown (BFng648_CR11) 2001; 153 TD Bunney (BFng648_CR24) 2009; 49 W Zhang (BFng648_CR13) 2000; 67 M Morita (BFng648_CR9) 2010; 15 TD Bunney (BFng648_CR25) 2006; 21 GH Zhang (BFng648_CR12) 2010; 5 SG Rhee (BFng648_CR23) 2001; 70 FR Zhang (BFng648_CR20) 2009; 361 |
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| Title | Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1 |
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