A neurohybrid memristive system for adaptive stimulation of hippocampus

We propose a hybrid memristve neuromorphic system for stimulating hippocampus regions bypassing damaged areas. Synaptic plasticity properties of the system allow close-loop adaptive control of neural dynamics. We implement the simplest version of this system which consists of two neuron-like generat...

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Veröffentlicht in:Chaos, solitons and fractals Jg. 146; S. 110804
Hauptverfasser: Gerasimova, S.A., Lebedeva, A.V., Fedulina, A., Koryazhkina, M., Belov, A.I., Mishchenko, M.A., Matveeva, M., Guseinov, D., Mikhaylov, A.N., Kazantsev, V.B., Pisarchik, A.N.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Elsevier Ltd 01.05.2021
Schlagworte:
Adaptive stimulation technology
Hippocampal slice
Memristive device
Neuromorphic system
Neuron
Neuronal synaptic plasticity
Neuromorphic system
Hippocampal slice
Neuron
Adaptive stimulation technology
Neuronal synaptic plasticity
Memristive device
ISSN:0960-0779, 1873-2887
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Zusammenfassung:We propose a hybrid memristve neuromorphic system for stimulating hippocampus regions bypassing damaged areas. Synaptic plasticity properties of the system allow close-loop adaptive control of neural dynamics. We implement the simplest version of this system which consists of two neuron-like generators coupled by a memristive device, and two fiber-optic channels to transmit signals from the generators directly to living cells to stimulate hippocampus regions. The adaptive stimulation nature of the neural cells is provided by a stochastic response of the self-learning memristive device to the signal of the neuron-like generator. A biological model of impaired functioning of the perforating pathway in the rat hippocampus is implemented by damaging the CA3 region, on the base of the electrophysiological signal changes in normal and pathological conditions. The proposed adaptive stimulation technology demonstrates the possibility of restoring the functionality of the perforating pathway by introducing the neuromorphic system into the hippocampus to replace lost areas.
ISSN:0960-0779
1873-2887
DOI:10.1016/j.chaos.2021.110804