The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya

Two clinical trials that used Falcidin (Cosmos Ltd., Nairobi, Kenya), the antifolate combination of pyrimethamine/sulfadoxine (PM/SD), as treatment for non-severe falciparum malaria in children at Kilifi, Kenya in 1987-1988 and 1993-1995 have presented an opportunity to assess in vitro the susceptib...

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Vydané v:	The American journal of tropical medicine and hygiene Ročník 62; číslo 3; s. 396
Hlavní autori:	Mberu, E K, Mosobo, M K, Nzila, A M, Kokwaro, G O, Sibley, C H, Watkins, W M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.03.2000
Predmet:	Animals Antimalarials - pharmacology Child Child, Preschool Dihydropteroate Synthase - genetics Drug Resistance Humans Infant Mutation Parasitic Sensitivity Tests Plasmodium falciparum - drug effects Pyrimethamine - pharmacology Sulfadoxine - pharmacology Tetrahydrofolate Dehydrogenase - genetics Time Factors
ISSN:	0002-9637
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