Anionic Sites and the Mechanisms of Proteinuria

Proteinuria is the hallmark of glomerular injury, and the study of its mechanisms remains a subject of considerable interest. In recent years, physiologic, ultrastructural, immunochemical, and biochemical techniques have established the importance to normal glomerular structure and permeability of n...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 309; no. 17; pp. 1050 - 1052
Main Authors: Cotran, Ramzi S, Rennke, Helmut G
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 27.10.1983
Subjects:
Anions
Basement Membrane - analysis
Biopsy
Congenital diseases
Defects
Diabetes
Disease
Experiments
Heparan sulfate
Heparitin Sulfate - metabolism
Humans
Kidney Glomerulus - analysis
Permeability
Proteins
Proteinuria
Proteinuria - etiology
Rodents
ISSN:0028-4793, 1533-4406
Online Access:Get full text
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Summary:Proteinuria is the hallmark of glomerular injury, and the study of its mechanisms remains a subject of considerable interest. In recent years, physiologic, ultrastructural, immunochemical, and biochemical techniques have established the importance to normal glomerular structure and permeability of negatively charged molecular groups in the glomerular basement membrane — the so-called glomerular anionic sites or polyanions. Histochemists have long known that the glomerulus is rich in anionic sites, since it stains strongly with such polycationic reagents as colloidal iron and alcian blue. Indeed, a role for polyanions in glomerular permeability was suggested by Michael et al. in 1970 on the . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198310273091709