Approach to the Paediatric Patient With Suspected Pheochromocytoma or Paraganglioma Versus Neuroblastoma

Catecholamine-producing tumors of childhood include neuroblastic tumors, phaeochromocytoma, and paraganglioma (PPGL). PPGL and neuroblastic tumors can arise in similar anatomical locations and clinical presentations can overlap, resulting in diagnostic challenges. Distinguishing between these tumor...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism Vol. 110; no. 3; p. 855
Main Authors: Hendriks, A Emile J, Burns, Charlotte, Fleming, Ben, Harper, Ines, Hook, Elizabeth, Armstrong, Ruth, Pamporaki, Christina, Eisenhofer, Graeme, Murray, Matthew J, Casey, Ruth T
Format: Journal Article
Language:English
Published: United States 18.02.2025
Subjects:
Adrenal Gland Neoplasms - diagnosis
Adrenal Gland Neoplasms - pathology
Adrenal Gland Neoplasms - therapy
Child
Diagnosis, Differential
Humans
Neuroblastoma - diagnosis
Neuroblastoma - pathology
Neuroblastoma - therapy
Paraganglioma - diagnosis
Paraganglioma - pathology
Paraganglioma - therapy
Pelvic Neoplasms - diagnosis
Pelvic Neoplasms - pathology
Pelvic Neoplasms - therapy
Pheochromocytoma - diagnosis
Pheochromocytoma - pathology
Pheochromocytoma - therapy
Retroperitoneal Neoplasms - diagnosis
neuroblastoma
neuroblastic tumours
phaeochromocytoma
paraganglioma
ISSN:1945-7197, 1945-7197
Online Access:Get more information
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Description
Summary:Catecholamine-producing tumors of childhood include neuroblastic tumors, phaeochromocytoma, and paraganglioma (PPGL). PPGL and neuroblastic tumors can arise in similar anatomical locations and clinical presentations can overlap, resulting in diagnostic challenges. Distinguishing between these tumor types is critical as management and long-term surveillance strategies differ depending on the diagnosis. Herein we describe 2 clinical cases and illustrate key considerations in the diagnostic workup of a neuroblastoma vs PPGL for patients presenting with adrenal, pelvic, and retroperitoneal masses in childhood.
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ISSN:1945-7197
1945-7197
DOI:10.1210/clinem/dgae603