Complete genome analysis identifies Tvärminne avian virus as a candidate new species within the genus Orthoreovirus

Orthoreoviruses have been associated with a variety of diseases in domesticated poultry and wild-living birds. In 2002, a reovirus strain named Tvärminne avian virus (TVAV), was identified in Finland in a crow showing neurological disorders. The objective of this study was the molecular characteriza...

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Bibliographic Details
Published in:Journal of general virology Vol. 95; no. Pt 4; p. 898
Main Authors: Dandár, Eszter, Huhtamo, Eili, Farkas, Szilvia L, Oldal, Miklós, Jakab, Ferenc, Vapalahti, Olli, Bányai, Krisztián
Format: Journal Article
Language:English
Published: England 01.04.2014
Subjects:
Animals
Birds
Cluster Analysis
Finland
Genome, Viral
Molecular Sequence Data
Orthoreovirus, Avian - classification
Orthoreovirus, Avian - genetics
Orthoreovirus, Avian - isolation & purification
Phylogeny
RNA, Viral - genetics
Sequence Analysis, DNA
Finland
ISSN:1465-2099, 1465-2099
Online Access:Get more information
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Summary:Orthoreoviruses have been associated with a variety of diseases in domesticated poultry and wild-living birds. In 2002, a reovirus strain named Tvärminne avian virus (TVAV), was identified in Finland in a crow showing neurological disorders. The objective of this study was the molecular characterization of this novel reovirus strain. Genome sequencing was performed by combining semiconductor sequencing and traditional capillary sequencing. Sequence and phylogenetic analyses showed that TVAV shares low nucleotide sequence identity with other reoviruses (range for each gene, 31-72 %) including strains belonging to the species Avian orthoreovirus. The most closely related reovirus strain was an isolate identified in Steller sea lion. Our data indicate that TVAV is a divergent reovirus of avian origin that may be the first representative of a distinct virus species within the genus Orthoreovirus.
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ISSN:1465-2099
1465-2099
DOI:10.1099/vir.0.060699-0